260010 | Demethylasterriquinone B1 - CAS 78860-34-1 - Calbiochem

260010
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₃₂H₃₀N₂O₄ 78860-34-1

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      260010-5MG
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          Plastic ampoule 5 mg
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          Description
          OverviewA cell-permeable unsymmetrical bis-indolylquinone insulin mimic with anti-diabetic activity in animal models. Selectively stimulates insulin receptor (IR) tyrosine kinase activity (EC50 ~ 6 µM in CHO•IR cells), while showing little effect towards IGF-1R, EGFR, or PDGFR. Also acts as an agonist for the neurotrophin receptors TrkA, B, and C in both cortical neurons and dorsal root ganglion neurons (~ 20 µM). DMAQ-B1 and insulin show differential effects on cellular gene expression profiles and DMAQ-B1 is a more selective agonist than insulin for the IR-mediated activation of PI-3 kinase/Akt pathway.
          Catalogue Number260010
          Brand Family Calbiochem®
          SynonymsL-783,281, DMAQ-B1, DAQ B1, 2-[2-(1,1-Dimethylallyl)-1H-indol-3-yl]-3,6-dihydroxy-5-[7-(3-methylbut-2-enyl)-1H-indol-3-yl][1,4]benzoquinone, 2,5-Dihydroxy-3-[7-(3-methyl-but-2-enyl)-1H-indol-3-yl]-6-[2-(1,1-dimethyl-allyl)-1H-indol-3-yl]-[1,4]benzoquinone
          References
          ReferencesWebster, N.J., et al. 2003. Chembiochem 4, 379.
          Pirrung, M.C., et al. 2002. J. Org. Chem. 6, 23.
          Westerlund, J., et al. 2002. Diabetes 51, S50.
          Roper, M.G., et al. 2002. Diabetes 51, S43.
          Air, E.L., et al. 2002. Nat. Med. 8, 179.
          Wilkie, N., et al. 2001. J. Neurochem. 78, 1135.
          Salituro, G.M., et al. 2001. Recent Prog. Horm. Res. 56, 107.
          Liu, K., et al. 2000. J. Med. Chem. 43, 3487.
          Zhang, B., et al. 1999. Science 284, 974.
          Product Information
          CAS number78860-34-1
          ATP CompetitiveN
          FormBluish black solid
          Hill FormulaC₃₂H₃₀N₂O₄
          Chemical formulaC₃₂H₃₀N₂O₄
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetInsulin receptor (IR) tyrosine kinase activity
          Primary Target IC<sub>50</sub>EC50 ~ 6 µM stimulating insulin receptor (IR) tyrosine kinase activity in CHO•IR cells
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped with Blue Ice or with Dry Ice
          Toxicity Irritant
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          260010

          References

          Reference overview
          Webster, N.J., et al. 2003. Chembiochem 4, 379.
          Pirrung, M.C., et al. 2002. J. Org. Chem. 6, 23.
          Westerlund, J., et al. 2002. Diabetes 51, S50.
          Roper, M.G., et al. 2002. Diabetes 51, S43.
          Air, E.L., et al. 2002. Nat. Med. 8, 179.
          Wilkie, N., et al. 2001. J. Neurochem. 78, 1135.
          Salituro, G.M., et al. 2001. Recent Prog. Horm. Res. 56, 107.
          Liu, K., et al. 2000. J. Med. Chem. 43, 3487.
          Zhang, B., et al. 1999. Science 284, 974.

          Brochure

          Title
          Calbiochem Biologics 32.2
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision15-June-2008 RFH
          SynonymsL-783,281, DMAQ-B1, DAQ B1, 2-[2-(1,1-Dimethylallyl)-1H-indol-3-yl]-3,6-dihydroxy-5-[7-(3-methylbut-2-enyl)-1H-indol-3-yl][1,4]benzoquinone, 2,5-Dihydroxy-3-[7-(3-methyl-but-2-enyl)-1H-indol-3-yl]-6-[2-(1,1-dimethyl-allyl)-1H-indol-3-yl]-[1,4]benzoquinone
          DescriptionA cell-permeable unsymmetrical bis-indolylquinone insulin mimic with anti-diabetic activity in animal models. Selectively stimulates insulin receptor (IR) tyrosine kinase activity (EC50 ~6 µM in CHO•IR cells), while showing little effect towards IGF-1R, EGFR, or PDGFR. Also acts as an agonist for the neurotrophin receptors TrkA, B, and C in both cortical neurons and dorsal root ganglion neurons (~20 µM). DMAQ-B1 and insulin show differential effects on cellular gene expression profiles and DMAQ-B1 is a more selective agonist than insulin for the IR-mediated activation of PI-3 kinase/Akt pathway.
          FormBluish black solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number78860-34-1
          Chemical formulaC₃₂H₃₀N₂O₄
          Structure formulaStructure formula
          Purity≥95% by HPLC
          SolubilityDMSO (50 mg/ml)
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Irritant
          ReferencesWebster, N.J., et al. 2003. Chembiochem 4, 379.
          Pirrung, M.C., et al. 2002. J. Org. Chem. 6, 23.
          Westerlund, J., et al. 2002. Diabetes 51, S50.
          Roper, M.G., et al. 2002. Diabetes 51, S43.
          Air, E.L., et al. 2002. Nat. Med. 8, 179.
          Wilkie, N., et al. 2001. J. Neurochem. 78, 1135.
          Salituro, G.M., et al. 2001. Recent Prog. Horm. Res. 56, 107.
          Liu, K., et al. 2000. J. Med. Chem. 43, 3487.
          Zhang, B., et al. 1999. Science 284, 974.