260961 | DNA-PK Inhibitor II - CAS 154447-35-5 - Calbiochem

260961
Price could not be retrieved
Minimum Quantity needs to be mulitiple of
Upon Order Completion More Information
You Saved ()
 
Request Pricing
Limited AvailabilityLimited Availability
Stocked 
Discontinued
Limited Quantities Available
Available
    Remaining : Will advise
      Remaining : Will advise
      Will advise
      Contact Customer Service
      View Pricing & Availability
      Click To Print This Page

      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₇H₁₅NO₃ 154447-35-5

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      260961-5MG
      Retrieving availability...
      Limited AvailabilityLimited Availability
      Stocked 
      Discontinued
      Limited Quantities Available
      Available
        Remaining : Will advise
          Remaining : Will advise
          Will advise
          Contact Customer Service

          Plastic ampoule 5 mg
          Retrieving price...
          Price could not be retrieved
          Minimum Quantity needs to be mulitiple of
          Upon Order Completion More Information
          You Saved ()
           
          Request Pricing
          Description
          OverviewA cell-permeable benzochromenone compound that acts as a potent, specific, reversible, and ATP-competitive inhibitor of DNA-PK with an IC50 of 0.23 µM. It is highly selective towards DNA-PK over PI3K-related kinases (IC50 = 13 µM for PI 3-K and > 100 µM for ATM and ATR) and has no effect on PARP-1. Inhibits DNA-PK-mediated, but not PARP-1-mediated, cellular DNA DSB (double strand break) repair and PLDR (potentially lethal damage recovery) following IR (ionizing radiation). Shown to sensitize both proliferating and quiescent cells to IR.
          Catalogue Number260961
          Brand Family Calbiochem®
          SynonymsNU7026, DNA-Dependent Protein Kinase Inhibitor II, 2-(Morpholin-4-yl)-benzo[h]chromen-4-one, LY293646
          References
          ReferencesWillmore, E., et al. 2004. Blood,103, 4659.
          Hollick, J.J., et al. 2003. Bioorg. Med. Chem. Lett. 13, 3083.
          Veuger, S.J., et al. 2003. Cancer Res. 63, 6008.
          Vlahos, C.J., et al. 1994. J. Biol. Chem. 269, 5241.
          Product Information
          CAS number154447-35-5
          ATP CompetitiveY
          FormCrystalline solid
          Hill FormulaC₁₇H₁₅NO₃
          Chemical formulaC₁₇H₁₅NO₃
          ReversibleY
          Structure formula ImageStructure formula Image
          Applications
          ApplicationDNA-PK Inhibitor II, CAS 154447-35-5, is a cell-permeable, potent, specific, reversible, and ATP-competitive inhibitor of DNA-PK (IC50 = 230 nM).
          Biological Information
          Primary TargetDNA-PK
          Primary Target IC<sub>50</sub>0.23 µM against DNA-PK
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Carcinogenic / Teratogenic
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          260961

          References

          Reference overview
          Willmore, E., et al. 2004. Blood,103, 4659.
          Hollick, J.J., et al. 2003. Bioorg. Med. Chem. Lett. 13, 3083.
          Veuger, S.J., et al. 2003. Cancer Res. 63, 6008.
          Vlahos, C.J., et al. 1994. J. Biol. Chem. 269, 5241.

          Brochure

          Title
          Biologics 33.1 ( 1.37 MB )
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision27-January-2010 RFH
          SynonymsNU7026, DNA-Dependent Protein Kinase Inhibitor II, 2-(Morpholin-4-yl)-benzo[h]chromen-4-one, LY293646
          DescriptionA cell-permeable, potent, specific, reversible, and ATP-competitive inhibitor of DNA-PK (IC50 = 230 nM). Reported to be highly selective for DNA-PK compared to PI3 K-related kinases (IC50 = 13 µM for PI 3-K and > 100 µM for ATM and ATR). Exhibits no inhibitory effect on PARP-1. Shown to inhibit DNA-PK-mediated, but not PARP-1-mediated, cellular DNA double strand break (DSB) repair and potentially lethal damage recovery (PLDR) following ionizing radiation (IR). Also shown to sensitize both proliferating and quiescent cells to IR.
          FormCrystalline solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number154447-35-5
          Chemical formulaC₁₇H₁₅NO₃
          Structure formulaStructure formula
          Purity≥95% by HPLC
          SolubilityDMSO (2 mg/ml) or Methanol (700 µg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Carcinogenic / Teratogenic
          ReferencesWillmore, E., et al. 2004. Blood,103, 4659.
          Hollick, J.J., et al. 2003. Bioorg. Med. Chem. Lett. 13, 3083.
          Veuger, S.J., et al. 2003. Cancer Res. 63, 6008.
          Vlahos, C.J., et al. 1994. J. Biol. Chem. 269, 5241.