310500 | D-erythro-Sphingosine, N,N-Dimethyl- - CAS 119567-63-4 - Calbiochem

310500
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₀H₄₁NO₂ 119567-63-4

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      310500-5MG
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          Plastic ampoule 5 mg
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          Description
          OverviewA cell-permeable and reversible inhibitor of protein kinase C (PKC; IC50 = 12 µM) and stimulates Src kinase activity. Useful for inhibiting cell surface expression of selectins that promote adhesion of leukocytes or tumor cells to platelets and endothelial cells. Induces apoptosis in human leukemia HL-60 cells. An inhibitor of sphingosine kinase.
          Catalogue Number310500
          Brand Family Calbiochem®
          SynonymsDMS, SK Inhibitor III, Sphingosine Kinase Inhibitor III
          References
          ReferencesCuvillier, O., et al. 1996. Nature 381, 800.
          Ohta, H., et al. 1995. Cancer Res. 55, 691.
          Kimura, S., et al. 1992. Biochem. Pharmacol. 44, 1585.
          Hanada, K., et al. 1991. Biochemistry 30, 11682.
          Igarashi, Y., et al. 1990. J. Biol. Chem. 265, 5385.
          Product Information
          CAS number119567-63-4
          ATP CompetitiveN
          FormWaxy solid/Clear oil
          Hill FormulaC₂₀H₄₁NO₂
          Chemical formulaC₂₀H₄₁NO₂
          ReversibleY
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetPKC
          Primary Target IC<sub>50</sub>12 µM against PKC
          Purity≥98% by TLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          R PhraseR: 36/37/38

          Irritating to eyes, respiratory system and skin.
          S PhraseS: 26-36

          In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
          Wear suitable protective clothing.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Irritant
          Storage -20°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 weeks at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          310500

          References

          Reference overview
          Cuvillier, O., et al. 1996. Nature 381, 800.
          Ohta, H., et al. 1995. Cancer Res. 55, 691.
          Kimura, S., et al. 1992. Biochem. Pharmacol. 44, 1585.
          Hanada, K., et al. 1991. Biochemistry 30, 11682.
          Igarashi, Y., et al. 1990. J. Biol. Chem. 265, 5385.

          Brochure

          Title
          Bioactive Lipids Technical Bulletin
          Biologics 35.1
          PKC Pathway Poster PDF ( 676 KB )
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision11-January-2010 RFH
          SynonymsDMS, SK Inhibitor III, Sphingosine Kinase Inhibitor III
          DescriptionA cell-permeable and reversible inhibitor of protein kinase C (IC50 = 12 µM) and enhances src kinase activity. Useful for inhibiting cell surface expression of selectins that promote adhesion of leukocytes or tumor cells to platelets and endothelial cells. Induces apoptosis in human leukemia HL-60 cells.
          FormWaxy solid/Clear oil
          CAS number119567-63-4
          Chemical formulaC₂₀H₄₁NO₂
          Structure formulaStructure formula
          Purity≥98% by TLC
          SolubilityDMSO (5 mg/ml), Ethanol, or Methanol
          Storage -20°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 weeks at -20°C.
          Toxicity Irritant
          ReferencesCuvillier, O., et al. 1996. Nature 381, 800.
          Ohta, H., et al. 1995. Cancer Res. 55, 691.
          Kimura, S., et al. 1992. Biochem. Pharmacol. 44, 1585.
          Hanada, K., et al. 1991. Biochemistry 30, 11682.
          Igarashi, Y., et al. 1990. J. Biol. Chem. 265, 5385.