376650 | D-erythro-Sphingosine, N-Hexanoyl- - CAS 124753-97-5 - Calbiochem

376650
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₄H₄₇NO₃ 124753-97-5

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      376650-5MG
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          Plastic ampoule 5 mg
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          Description
          OverviewBiologically active, cell-permeable, non-physiological ceramide analog. Induces a dramatic arrest in the G0/G1 phase of the cell cycle. Activates MAP kinase. Activates protein phosphatase 2A (PP2A) at 10 nM. Inhibits diacylglycerol accumulation and phospholipase D (PLD) activation in fibroblasts. Induces apoptosis in MOLT-4 leukemia cells.
          Catalogue Number376650
          Brand Family Calbiochem®
          SynonymsC₆ Ceramide
          References
          ReferencesJayadev, S., et al. 1995. J. Biol. Chem. 270, 2047.
          Venable, M.E., et al. 1994. J. Biol. Chem. 269, 26040.
          Dobrowsky, R.T., et al. 1993. J. Biol. Chem. 268, 15523.
          Raines, M.A., et al. 1993. J. Biol. Chem. 268, 14572.
          Dobrowsky, R.T., and Hannun, Y.A. 1992. J. Biol. Chem. 267, 5048.
          Product Information
          CAS number124753-97-5
          ATP CompetitiveN
          FormWhite waxy solid
          Hill FormulaC₂₄H₄₇NO₃
          Chemical formulaC₂₄H₄₇NO₃
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetMAP kinase, protein phosphatase 2A (PP2A)
          Primary Target IC<sub>50</sub>Effective concentration: 10 nM in activating protein phosphatase 2A (PP2A)
          Purity≥98% by TLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          R PhraseR: 36/37/38

          Irritating to eyes, respiratory system and skin.
          S PhraseS: 26-36

          In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
          Wear suitable protective clothing.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Irritant
          Storage -20°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          376650

          References

          Reference overview
          Jayadev, S., et al. 1995. J. Biol. Chem. 270, 2047.
          Venable, M.E., et al. 1994. J. Biol. Chem. 269, 26040.
          Dobrowsky, R.T., et al. 1993. J. Biol. Chem. 268, 15523.
          Raines, M.A., et al. 1993. J. Biol. Chem. 268, 14572.
          Dobrowsky, R.T., and Hannun, Y.A. 1992. J. Biol. Chem. 267, 5048.

          Brochure

          Title
          Bioactive Lipids Technical Bulletin
          DNA Repair Pathway Poster
          MAP Kinases Technical Bulletin
          MAPK Pathway Poster ( 750 KB )
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision09-July-2008 RFH
          SynonymsC₆ Ceramide
          DescriptionBiologically active, cell-permeable, nonphysiological ceramide analog. Stimulates cytosolic serine/threonine protein phosphatase in T9 cells and induces phosphorylation on Thr-669 in A-431 cells by stimulation of ceramide-activated protein kinase. Induces a dramatic arrest in the Go/G1 phase of the cell cycle. Activates MAP kinase. Activates protein phosphatase 2A (PP2A) at 10 nM. Inhibits diacylglycerol accumulation and phospholipase D activation in fibroblasts. Induces apoptosis in Molt-4 leukemia cells.
          FormWhite waxy solid
          CAS number124753-97-5
          Chemical formulaC₂₄H₄₇NO₃
          Structure formulaStructure formula
          Purity≥98% by TLC
          SolubilityDMSO or Ethanol (25 mg/ml)
          Storage -20°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
          Toxicity Irritant
          ReferencesJayadev, S., et al. 1995. J. Biol. Chem. 270, 2047.
          Venable, M.E., et al. 1994. J. Biol. Chem. 269, 26040.
          Dobrowsky, R.T., et al. 1993. J. Biol. Chem. 268, 15523.
          Raines, M.A., et al. 1993. J. Biol. Chem. 268, 14572.
          Dobrowsky, R.T., and Hannun, Y.A. 1992. J. Biol. Chem. 267, 5048.