250233 | Cytochalasin B, Helminthosporium dematioideum - CAS 14930-96-2 - Calbiochem

250233
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₉H₃₇NO₅ 14930-96-2

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      250233-5MG
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          Alu drum 5 mg
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          Description
          OverviewCell-permeable fungal toxin. Inhibits cytoplasmic division by blocking the formation of contractile microfilaments. Inhibits cell movement and induces nuclear extrusion. Shortens actin filaments by blocking monomer addition at the fast-growing end of polymers. Inhibits glucose transport and platelet aggregation. Blocks adenosine-induced apoptotic body formation without affecting activation of endogenous ADP-ribosylation in leukemia HL-60 cells.
          Catalogue Number250233
          Brand Family Calbiochem®
          References
          ReferencesTanaka, Y., et al. 1994. Exp. Cell Res. 213, 242.
          Theodoropoulos, P.A., et al. 1994. Biochem. Pharmacol. 47, 1875.
          Benya, P.D., and Padilla, S.R. 1993. Exp. Cell Res. 204, 268.
          Cairns, M.T., et al. 1991. J. Biol. Chem. 266, 8176.
          Nowak, D. 1990. Biomed. Biochim. Acta 49, 353.
          Wang, F., et al. 1990. Biochem. Biophys. Res. Commun. 171, 543.
          Edwards, S.W., and Lloyd, D. 1988. FEBS Lett. 227, 39.
          Product Information
          CAS number14930-96-2
          ATP CompetitiveN
          FormWhite solid
          Hill FormulaC₂₉H₃₇NO₅
          Chemical formulaC₂₉H₃₇NO₅
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          ApplicationCytochalasin B, Helminthosporium dematioideum - CAS 14930-96-2, is a cell-permeable fungal toxin that inhibits cytoplasmic division by blocking the formation of contractile microfilaments.
          Biological Information
          Primary TargetBlocking the formation of contractile microfilaments
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSRO0205000
          Safety Information
          R PhraseR: 26/27/28-63

          Very toxic by inhalation, in contact with skin and if swallowed.
          Possible risk of harm to the unborn child.
          S PhraseS: 22-36/37/39-45

          Do not breathe dust.
          Wear suitable protective clothing, gloves and eye/face protection.
          In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Highly Toxic & Carcinogenic / Teratogenic
          Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution store in the refrigerator (4°C). Stock solutions are stable for up to 3 months at 4°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          250233

          References

          Reference overview
          Tanaka, Y., et al. 1994. Exp. Cell Res. 213, 242.
          Theodoropoulos, P.A., et al. 1994. Biochem. Pharmacol. 47, 1875.
          Benya, P.D., and Padilla, S.R. 1993. Exp. Cell Res. 204, 268.
          Cairns, M.T., et al. 1991. J. Biol. Chem. 266, 8176.
          Nowak, D. 1990. Biomed. Biochim. Acta 49, 353.
          Wang, F., et al. 1990. Biochem. Biophys. Res. Commun. 171, 543.
          Edwards, S.W., and Lloyd, D. 1988. FEBS Lett. 227, 39.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision06-April-2009 JSW
          DescriptionCell-permeable fungal toxin. Inhibits cytoplasmic division by blocking the formation of contractile microfilaments. Inhibits cell movement and induces nuclear extrusion. Shortens actin filaments by blocking monomer addition at the fast growing end of polymers. Inhibits glucose transport and platelet aggregation. Blocks adenosine-induced apoptotic body formation without affecting activation of endogenous ADP-ribosylation in leukemia HL-60 cells.
          FormWhite solid
          CAS number14930-96-2
          RTECSRO0205000
          Chemical formulaC₂₉H₃₇NO₅
          Structure formulaStructure formula
          Purity≥98% by HPLC
          SolubilityDMSO (50 mg/ml) or Methanol (20 mg/ml). Poor quality DMSO will cause degradation of the product, so high quality DMSO is recommended.
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution store in the refrigerator (4°C). Stock solutions are stable for up to 3 months at 4°C.
          Toxicity Highly Toxic & Carcinogenic / Teratogenic
          Merck USA index14, 2790
          ReferencesTanaka, Y., et al. 1994. Exp. Cell Res. 213, 242.
          Theodoropoulos, P.A., et al. 1994. Biochem. Pharmacol. 47, 1875.
          Benya, P.D., and Padilla, S.R. 1993. Exp. Cell Res. 204, 268.
          Cairns, M.T., et al. 1991. J. Biol. Chem. 266, 8176.
          Nowak, D. 1990. Biomed. Biochim. Acta 49, 353.
          Wang, F., et al. 1990. Biochem. Biophys. Res. Commun. 171, 543.
          Edwards, S.W., and Lloyd, D. 1988. FEBS Lett. 227, 39.