239835 Cyclosporin A, Tolypocladium inflatum - CAS 59865-13-3 - Calbiochem

239835
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₆₂H₁₁₁N₁₁O₁₂ 59865-13-3

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      239835-100MG
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          Plastic ampoule 100 mg
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          Description
          OverviewCyclic oligopeptide with immunosuppressant properties. Induces apoptosis in rat thymocytes and in the murine B cell lymphoma cell line, WEH1-231. However, prevents anti-IgM and ionomycin-induced apoptosis in BLB cell lines. The complex of cyclosporin A with cyclophilin inhibits protein phosphatase 2B with nanomolar affinity. Inhibits nitric oxide synthesis induced by interleukin-1α, lipopolysaccharides, and TNF-α. Induces cardiomyocytes from embryonic stem cells.
          Catalogue Number239835
          Brand Family Calbiochem®
          References
          ReferencesYan, P., et al. 2008. Biochem. Biophys. Res. Commun. in press.
          Hattori, Y., and Naranishi, N. 1995. Cell Immunol. 165, 7.
          Marumo, T., et al. 1995. Hypertension 25, 764.
          Crabtree, G.R., and Clipstone, N.A. 1994. Annu. Rev. Biochem. 63, 1045.
          Gottschalk, A.R., et al. 1994. Proc. Natl. Acad. Sci. USA 91, 7350.
          Montague, J.W., et al. 1994. J. Biol. Chem. 269, 18877.
          Fast, D.J., et al. 1993. J. Interferon Res. 13, 235.
          Liu, J. 1993. Trends Pharmacol. Sci. 14, 182.
          Fruman, D.A., et al. 1992. Proc. Natl. Acad. Sci. USA 89, 3686.
          Product Information
          CAS number59865-13-3
          ATP CompetitiveN
          FormWhite to off-white solid
          Hill FormulaC₆₂H₁₁₁N₁₁O₁₂
          Chemical formulaC₆₂H₁₁₁N₁₁O₁₂
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetNOS induced by interlukin-1-α
          Purity≥97% (dry basis)
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSGZ4120000
          Safety Information
          R PhraseR: 40

          Limited evidence of a carcinogenic effect.
          S PhraseS: 22-24/25-36/37

          Do not breathe dust.
          Avoid contact with skin and eyes.
          Wear suitable protective clothing and gloves.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Carcinogenic / Teratogenic
          Storage +2°C to +8°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          239835

          References

          Reference overview
          Yan, P., et al. 2008. Biochem. Biophys. Res. Commun. in press.
          Hattori, Y., and Naranishi, N. 1995. Cell Immunol. 165, 7.
          Marumo, T., et al. 1995. Hypertension 25, 764.
          Crabtree, G.R., and Clipstone, N.A. 1994. Annu. Rev. Biochem. 63, 1045.
          Gottschalk, A.R., et al. 1994. Proc. Natl. Acad. Sci. USA 91, 7350.
          Montague, J.W., et al. 1994. J. Biol. Chem. 269, 18877.
          Fast, D.J., et al. 1993. J. Interferon Res. 13, 235.
          Liu, J. 1993. Trends Pharmacol. Sci. 14, 182.
          Fruman, D.A., et al. 1992. Proc. Natl. Acad. Sci. USA 89, 3686.

          Brochure

          Title
          Nitric Oxide and Oxidative Stress Brochure
          Protein Phosphatases Technical Bulletin

          Citations

          Title
        • Justin C. Mason, et al. (2004) Decay-accelerating actor induction on vascular endothelium by vascular endothelial growth factor (VEGF) is mediated via a VEGF receptor-2 (VEGF-R2)- and protein kinase C-α/ε (PKCα/ε)-dependent cytoprotective signaling pathway a. Journal of Biological Chemistry 279, 41611-41618.
        • Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision22-January-2009 JSW
          DescriptionMaterial is a nonpolar cyclic oligopeptide with immunosuppressant activity. Appears to act via interaction with the intracellular protein cyclophilin. The cyclophilin-cyclosporin A complex is a potent inhibitor of the protein phosphatase activity of calcineurin (protein phosphatase 2B, PP2B). Induces apoptosis in rat thymocytes and in the murine B-cell lymphoma cell line, WEHI-231; however, it prevents anti-IgM and ionomycin-induced apoptosis in BLB cell lines. Inhibits nitric oxide synthesis induced by interleukin 1α, lipopolysaccharides, and TNFα. Induces cardiomyocytes from embryonic stem cells.
          FormWhite to off-white solid
          CAS number59865-13-3
          RTECSGZ4120000
          Chemical formulaC₆₂H₁₁₁N₁₁O₁₂
          Structure formulaStructure formula
          Purity≥97% (dry basis)
          SolubilityDMSO (25 mg/ml), Ethanol, Methanol, or chloroform
          Storage +2°C to +8°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Carcinogenic / Teratogenic
          Merck USA index14, 2752
          ReferencesYan, P., et al. 2008. Biochem. Biophys. Res. Commun. in press.
          Hattori, Y., and Naranishi, N. 1995. Cell Immunol. 165, 7.
          Marumo, T., et al. 1995. Hypertension 25, 764.
          Crabtree, G.R., and Clipstone, N.A. 1994. Annu. Rev. Biochem. 63, 1045.
          Gottschalk, A.R., et al. 1994. Proc. Natl. Acad. Sci. USA 91, 7350.
          Montague, J.W., et al. 1994. J. Biol. Chem. 269, 18877.
          Fast, D.J., et al. 1993. J. Interferon Res. 13, 235.
          Liu, J. 1993. Trends Pharmacol. Sci. 14, 182.
          Fruman, D.A., et al. 1992. Proc. Natl. Acad. Sci. USA 89, 3686.
          Citation
        • Justin C. Mason, et al. (2004) Decay-accelerating actor induction on vascular endothelium by vascular endothelial growth factor (VEGF) is mediated via a VEGF receptor-2 (VEGF-R2)- and protein kinase C-α/ε (PKCα/ε)-dependent cytoprotective signaling pathway a. Journal of Biological Chemistry 279, 41611-41618.