239803 Cyclopamine, V. californicum - CAS 4449-51-8 - Calbiochem

239803
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₇H₄₁NO₂ 4449-51-8

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      239803-1MG
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          Glass bottle 1 mg
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          239803-5MG
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              Glass bottle 5 mg
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              Description
              OverviewA cell-permeable steroidal alkaloid and cholesterol mimic that displays both teratogenic and antitumor activities. It disrupts cholesterol bio-synthesis and specifically antagonizes shh (Sonic Hedgehog) signaling pathway through direct interaction with Smo (smoothened), a distant relative of G-protein-coupled receptors. A valuable tool for studying the involvement of shh signaling in the development of various tumors. Tomatidine (Cat. No. 614350) can be used as a negative control. Also available as a 10 mM solution in Ethanol (Cat. No. 239806).
              Catalogue Number239803
              Brand Family Calbiochem®
              SynonymsShh Signaling Antagonist I
              References
              ReferencesBerman, D.M., et al. 2003. Nature, 425, 846.
              Thayer, S.P., et al. 2003. Nature, 425, 851.
              Watkins, D.N., et al. 2003. Nature 422, 313.
              Chen, J.K., et al. 2002. Proc. Natl. Acad. Sci. USA 99, 14071.
              Berman, D.M., et al. 2002. Science 297, 1559.
              Taipale, J., et al. 2000. Nature 406, 1005.
              Kim, S.K., and Melton, D.A. 1998. Proc. Natl. Acad. Sci. USA 95, 13036.
              Cooper, M.K., et al. 1998. Science 280, 1603.
              Incardona, J.P., et al. 1998. Development 125, 3553.
              Product Information
              CAS number4449-51-8
              ATP CompetitiveN
              FormOff-white solid
              Hill FormulaC₂₇H₄₁NO₂
              Chemical formulaC₂₇H₄₁NO₂
              ReversibleN
              Structure formula ImageStructure formula Image
              Applications
              Biological Information
              Primary TargetHh signaling in Shh-light2 assay
              Primary Target IC<sub>50</sub>20 nM
              Purity≥97% by HPLC
              Physicochemical Information
              Cell permeableY
              Dimensions
              Materials Information
              Toxicological Information
              Safety Information according to GHS
              RTECSGY0750000
              Safety Information
              Product Usage Statements
              Storage and Shipping Information
              Ship Code Shipped with Blue Ice or with Dry Ice
              Toxicity Carcinogenic / Teratogenic
              Storage -20°C
              Protect from Light Protect from light
              Do not freeze Ok to freeze
              Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
              Packaging Information
              Packaged under inert gas Packaged under inert gas
              Transport Information
              Supplemental Information
              Specifications

              Documentation

              SDS

              Title

              Safety Data Sheet (SDS) 

              Certificates of Analysis

              TitleLot Number
              239803

              References

              Reference overview
              Berman, D.M., et al. 2003. Nature, 425, 846.
              Thayer, S.P., et al. 2003. Nature, 425, 851.
              Watkins, D.N., et al. 2003. Nature 422, 313.
              Chen, J.K., et al. 2002. Proc. Natl. Acad. Sci. USA 99, 14071.
              Berman, D.M., et al. 2002. Science 297, 1559.
              Taipale, J., et al. 2000. Nature 406, 1005.
              Kim, S.K., and Melton, D.A. 1998. Proc. Natl. Acad. Sci. USA 95, 13036.
              Cooper, M.K., et al. 1998. Science 280, 1603.
              Incardona, J.P., et al. 1998. Development 125, 3553.

              Brochure

              Title
              Biologics 32.4 ( 1.19 MB )
              Biologics 33.2
              Calbiochem Biologics 32.1
              Data Sheet

              Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

              Revision01-October-2007 JSW
              SynonymsShh Signaling Antagonist I
              DescriptionA cell-permeable, steroidal alkaloid and cholesterol mimic that displays both teratogenic and anti-tumor properties. Disrupts cholesterol biosynthesis and specifically antagonizes shh (Sonic Hedgehog) signaling through direct interaction with Smo (smoothened), a protein that is related to G-protein-coupled receptors. Useful for studying the involvement of shh signaling in the development of various tumors. Tomatidine (Cat. No. 614350) can be used as a negative control.
              FormOff-white solid
              Intert gas (Yes/No) Packaged under inert gas
              CAS number4449-51-8
              RTECSGY0750000
              Chemical formulaC₂₇H₄₁NO₂
              Structure formulaStructure formula
              Purity≥97% by HPLC
              SolubilityDMSO (4 mg/ml), Ethanol (5 mg/ml), or DMF (10 mg/ml). Ethanol stock solutions may require warming to achieve complete solubilization.
              Storage -20°C
              Protect from light
              Do Not Freeze Ok to freeze
              Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
              Toxicity Carcinogenic / Teratogenic
              ReferencesBerman, D.M., et al. 2003. Nature, 425, 846.
              Thayer, S.P., et al. 2003. Nature, 425, 851.
              Watkins, D.N., et al. 2003. Nature 422, 313.
              Chen, J.K., et al. 2002. Proc. Natl. Acad. Sci. USA 99, 14071.
              Berman, D.M., et al. 2002. Science 297, 1559.
              Taipale, J., et al. 2000. Nature 406, 1005.
              Kim, S.K., and Melton, D.A. 1998. Proc. Natl. Acad. Sci. USA 95, 13036.
              Cooper, M.K., et al. 1998. Science 280, 1603.
              Incardona, J.P., et al. 1998. Development 125, 3553.