239783 Cyclooxygenase Inhibitor Set - Calbiochem

239783
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      Overview

      Replacement Information

      Key Specifications Table

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      239783-1SET
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          Glass bottle 1 set
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          Description
          OverviewContains 100 mg of Meloxicam (Cat. No. 444800), 5 mg of NS-398 (Cat. No. 349254), 5 mg of SC-560 (Cat. No. 565610), and 5 mg of Sulindac Sulfide (Cat. No. 574102).
          Catalogue Number239783
          Brand Family Calbiochem®
          References
          ReferencesFournier, D.B., et al. 2000. J. Cell Biochem. 77, 97.
          Crofford, L.J., et al. 2000. Arthritis Rheum. 43, 4.
          Masferrer, J.L., et al. 1999. Ann. N. Y. Acad Sci. 889, 84.
          Williams, C., et al. 1999. Ann. N. Y. Acad. Sci. 889, 72.
          Product Information
          FormSolid
          Applications
          Biological Information
          Primary TargetCOX-1
          Secondary targetCOX-2
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          R PhraseR: 22-42/43-63

          Harmful if swallowed.
          May cause sensitization by inhalation and skin contact.
          Possible risk of harm to the unborn child.
          S PhraseS: 36

          Wear suitable protective clothing.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Multiple Toxicity Values, refer to MSDS
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C).
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          239783

          References

          Reference overview
          Fournier, D.B., et al. 2000. J. Cell Biochem. 77, 97.
          Crofford, L.J., et al. 2000. Arthritis Rheum. 43, 4.
          Masferrer, J.L., et al. 1999. Ann. N. Y. Acad Sci. 889, 84.
          Williams, C., et al. 1999. Ann. N. Y. Acad. Sci. 889, 72.

          Brochure

          Title
          Alzheimer's Disease Brochure & Technical Guide
          Biologics 32.3 PDF ( 927 KB )
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision10-September-2007 RFH
          DescriptionCyclooxygenases (COX) act on arachidonic acid to generate prostaglandins. They exist either as COX-1 or COX-2. COX-1, a constitutive enzyme associated with the endoplasmic reticulum, is responsible for maintaining normal physiologic function. It is found throughout the body, especially in the GI tract, kidneys, and platelets and its inhibition by NSAID is reported to cause GI damage, renal dysfunction, and platelet abnormalities. COX-2 is an inducible enzyme that is mainly associated with the nuclear envelope. It's activity is induced by several growth factors, cytokines, and inflammatory signals. COX-2 expression is markedly increased in 85-90% of human colorectal adenocarcinomas, whereas COX-1 levels remain unchanged. Based on structural differences in the active sites of these isozymes, a new drug has been developed that specifically inhibits only the COX-2 activity. COX-2 inhibitors have the potential to provide the traditional benefits of NSAID with significantly reduced incidence of endoscopic ulcers. Hence, they offer greater therapeutic promise in the treatment of inflammation and cancer. This inhibitor set provides 4 inhibitors for testing the inhibitory effects on COX-1 and COX-2.
          FormSolid
          Intert gas (Yes/No) Packaged under inert gas
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C).
          Toxicity Multiple Toxicity Values, refer to MSDS
          ReferencesFournier, D.B., et al. 2000. J. Cell Biochem. 77, 97.
          Crofford, L.J., et al. 2000. Arthritis Rheum. 43, 4.
          Masferrer, J.L., et al. 1999. Ann. N. Y. Acad Sci. 889, 84.
          Williams, C., et al. 1999. Ann. N. Y. Acad. Sci. 889, 72.