238590 | Cucurbitacin I, Cucumis sativus L. - CAS 2222-07-3 - Calbiochem

238590
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₃₀H₄₂O₇ 2222-07-3

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      238590-1MG
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          Plastic ampoule 1 mg
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          Description
          OverviewA cell-permeable and irreversible bitter triterpenoid compound (NCI identifier: NSC 521777) that displays anti-proliferative and antitumor properties both in vitro and in vivo. Acts as a potent and highly selective inhibitor of Janus kinase/signal transducer and activator of transcription 3 (JAK/STAT3) signaling pathway. It suppresses STAT3 tyrosine phosphorylation in v-Src-transformed NIH 3T3 cells and human lung adenocarcinoma A549 cells (IC50 = 500 nM), resulting in inhibition of STAT3 DNA-binding and STAT3-mediated gene transcription. Shown to inhibit the growth of STAT3-transformed tumors in nude mice. Does not affect oncogenic pathways mediated by Ras, Akt, Erk1/2, or JNK.
          Catalogue Number238590
          Brand Family Calbiochem®
          SynonymsJSI-124, STAT3 Inhibitor XIV
          References
          ReferencesBlaskovich, M.A., et al. 2003. Cancer Res. 63, 1270.
          Product Information
          CAS number2222-07-3
          ATP CompetitiveN
          FormWhite solid
          Hill FormulaC₃₀H₄₂O₇
          Chemical formulaC₃₀H₄₂O₇
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          ApplicationCucurbitacin I, Cucumis sativus L., CAS 2222-07-3, is a cell-permeable anti-proliferative agent that acts as a potent and highly selective inhibitor of JAK/STAT3 signaling pathway.
          Biological Information
          Primary TargetJAK/STAT3
          Primary Target IC<sub>50</sub>500 nM suppressing STAT3 tyrosine phosphorylation in v-Src-transformed NIH 3T3 cells and human lung adenocarcinoma A549 cells
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSRC6200000
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          238590

          References

          Reference overview
          Blaskovich, M.A., et al. 2003. Cancer Res. 63, 1270.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision21-April-2011 JSW
          SynonymsJSI-124, STAT3 Inhibitor XIV
          DescriptionA cell-permeable and irreversible bitter triterpenoid compound (NCI identifier: NSC 521777) that exhibits anti-proliferative and anti-tumor properties both in vitro and in vivo. Acts as a potent and highly selective inhibitor of Janus kinase/Signal transducer and activator of transcription 3 (Jak/STAT3) signaling pathway. Reported to suppress STAT3 tyrosine phosphorylation in v-src-transformed NIH 3T3 cells and human lung adenocarcinoma A549 cells (IC50 = 500 nM), resulting in inhibition of STAT3 DNA-binding and STAT3-mediated gene transcription. Also shown to inhibit the growth of STAT3-transformed tumors in nude mice. Does not affect oncogenic pathways mediated by Ras, Akt1, ERK1/2, or JNK.
          FormWhite solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number2222-07-3
          RTECSRC6200000
          Chemical formulaC₃₀H₄₂O₇
          Structure formulaStructure formula
          Purity≥95% by HPLC
          SolubilityDMSO (100 mg/ml) or Ethanol (10 mg/ml)
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesBlaskovich, M.A., et al. 2003. Cancer Res. 63, 1270.