233630 Cryptotanshinone - CAS 35825-57-1 - Calbiochem

233630
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₉H₂₀O₃ 35825-57-1

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      233630-10MG
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          Plastic ampoule 10 mg
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          Description
          OverviewCryptotanshinone, a cell-permeable diterpene quinone and naturally occurring herbal constituent of Salvia miltiorrhiza Bunge (Danshen), is shown to inhibit the constitutive STAT3 Tyr705 phosphorylation in DU145 prostate cancer cells (>90% inhibition in 1 h at 7 µM) independent of the IL-6/JAK/STAT3 signaling pathway, resulting in a blockage of STAT3 dimerization, nuclear translocation, and STAT3-dependent transcription activity (by ~80% in 24 h at 7 µM). Cryptotanshinone is also reported to deplete cellular ATP level (by 75% in 12 h at 20 µM in C2C12 myotubes), resulting in an indirect activation of cellular AMPK pathways and an enhancement of insulin-stimulated cellular glucose uptake in C2C12 myotubes and 3T3-L1 adipocytes (by ~1.3- and 1.9-fold, respectively). Cryptotanshinone is demonstrated to be an orally active hypoglycemic agent in ob/ob mice, db/db mice, and ZDF rats in vivo (600 mg/kg/day).
          Catalogue Number233630
          Brand Family Calbiochem®
          SynonymsAMPK Signaling Activator VIII
          References
          ReferencesShin, D.S., et al. 2009. Cancer Res. 69, 193.
          Kim, E.J., et al. 2007. Mol. Pharmacol. 72, 62.
          Product Information
          CAS number35825-57-1
          FormOrange solid
          Hill FormulaC₁₉H₂₀O₃
          Chemical formulaC₁₉H₂₀O₃
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Purity≥95% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          S PhraseS: 22-24/25-36/37-45

          Do not breathe dust.
          Avoid contact with skin and eyes.
          Wear suitable protective clothing and gloves.
          In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          233630

          References

          Reference overview
          Shin, D.S., et al. 2009. Cancer Res. 69, 193.
          Kim, E.J., et al. 2007. Mol. Pharmacol. 72, 62.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision15-September-2009 RFH
          SynonymsAMPK Signaling Activator VIII
          DescriptionCryptotanshinone, a cell-permeable diterpene quinone and naturally occurring herbal constituent of Salvia miltiorrhiza Bunge (Danshen), is shown to inhibit the constitutive STAT3 Tyr705 phosphorylation in DU145 prostate cancer cells (>90% inhibition in 1 h at 7 µM) independent of the IL-6/JAK/STAT3 signaling pathway, resulting in a blockage of STAT3 dimerization, nuclear translocation, and STAT3-dependent transcription activity (by ~80% in 24 h at 7 µM). Cryptotanshinone is also reported to deplete cellular ATP level (by 75% in 12 h at 20 µM in C2C12 myotubes), resulting in an indirect activation of cellular AMPK pathways and an enhancement of insulin-stimulated cellular glucose uptake in C2C12 myotubes and 3T3-L1 adipocytes (by ~1.3- and 1.9-fold, respectively). Cryptotanshinone is demonstrated to be an orally active hypoglycemic agent in ob/ob mice, db/db mice, and ZDF rats in vivo (600 mg/kg/day).
          FormOrange solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number35825-57-1
          Chemical formulaC₁₉H₂₀O₃
          Structure formulaStructure formula
          Purity≥95% by HPLC
          SolubilityDMSO (5 mg/ml) or Ethanol (1 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesShin, D.S., et al. 2009. Cancer Res. 69, 193.
          Kim, E.J., et al. 2007. Mol. Pharmacol. 72, 62.