204882 | Complement C2, Human

204882
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      Overview

      Replacement Information

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      204882-50UG
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          Plastic ampoule 50 μg
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          Description
          OverviewNative, human C2 complement component. Single chain glycoprotein present in normal human serum at concentration of 20 µg/ml. Classical pathway activation results in assembly of the C1,C4b complex on target surfaces. Subsequent to binding of the C4b component to this complex, C2 is cleaved by the activated C1s subcomponent of C1 into C2a, the 63 kDa C-terminal fragment, and C2b, the 30 kDa N-terminal fragment. The smaller C2b fragment is released while the larger C2a fragment remains associated with the C1,C4b complex to form the C4b,C2a classical pathway C3 convertase enzyme. C2 concentration is based on functional activity measurements relative to a normal human serum standard pool.
          Catalogue Number204882
          Brand Family Calbiochem®
          References
          ReferencesAttwood, J.T., et al. 2001. Acta Paediatr. 90, 99.
          Product Information
          Activity≥4 × 10⁵ C₂H₅0 units/mg; ≥70% of the C2 activity in normal human serum on a mg/mg basis
          FormLiquid
          FormulationIn PBS, pH 6.0.
          Applications
          Biological Information
          Purity≥90% by SDS-PAGE
          SourcePrepared from plasma that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
          Concentration Label Please refer to vial label for lot-specific concentration
          Physicochemical Information
          ContaminantsC1, C3, C4, C5, IgG, IgA, IgM, albumin, Factor B, or hemopexin:
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Dry Ice Only
          Toxicity Standard Handling
          Storage ≤ -70°C
          Avoid freeze/thaw Avoid freeze/thaw
          Do not freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          204882

          References

          Reference overview
          Attwood, J.T., et al. 2001. Acta Paediatr. 90, 99.

          Citations

          Title
        • Inal J.M., and Schifferli, J.A., (2002) Journal of Immunology 168, 5213.
        • Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision27-May-2008 RFH
          DescriptionNative, human C2 complement component. Single chain glycoprotein present in normal human serum at concentration of 20 µg/ml. Classical pathway activation results in assembly of the C1,C4b complex on target surfaces. Subsequent to binding of the C4b component to this complex, C2 is cleaved by the activated C1s subcomponent of C1 into C2a, the 63 kDa C-terminal fragment, and C2b, the 30 kDa N-terminal fragment. The smaller C2b fragment is released while the larger C2a fragment remains associated with the C1,C4b complex to form the C4b,C2a classical pathway C3 convertase enzyme. C2 concentration is based on functional activity measurements relative to a normal human serum standard pool.
          FormLiquid
          FormulationIn PBS, pH 6.0.
          Concentration Label Please refer to vial label for lot-specific concentration
          SourcePrepared from plasma that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
          Purity≥90% by SDS-PAGE
          ContaminantsC1, C3, C4, C5, IgG, IgA, IgM, albumin, Factor B, or hemopexin:
          Activity≥4 × 10⁵ C₂H₅0 units/mg; ≥70% of the C2 activity in normal human serum on a mg/mg basis
          Storage ≤ -70°C
          Avoid freeze/thaw
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
          Toxicity Standard Handling
          ReferencesAttwood, J.T., et al. 2001. Acta Paediatr. 90, 99.
          Citation
        • Inal J.M., and Schifferli, J.A., (2002) Journal of Immunology 168, 5213.