204878 | Complement C1r, Human, Activated, Two-Chain Form

204878
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      Overview

      Replacement Information

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      204878-250UG
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          Plastic ampoule 250 μg
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          Description
          OverviewNative, human, activated, C1r complement component. Generally the non-activated form composed of a single-chain glycoprotein. Present in normal human serum at 34 µg/ml. Non-activated C1r is found in circulating blood plasma as a dimer that associates with one C1q molecule and two C1s molecules to form the first component of complement (C1). Ensuing C1q binding to classical complement pathway activators, each C1r proenzyme monomer is activated by cleavage into two disulfide-linked fragments of M.W. 60,000 and 35,000. The 35 kDa peptide contains C1r enzymatic active site. Activated C1r continues activation via classical pathway by cleaving, and thus activating C1s.
          Catalogue Number204878
          Brand Family Calbiochem®
          References
          ReferencesVilliers, C.L., et al. 1983. Biochem. J. 215, 369.
          Ziccardi, R.J. and Cooper, N.R. 1976. J. Immunol. 116, 496.
          Product Information
          CAS number80295-34-7
          FormLiquid
          FormulationIn 140 mM NaCl, 10 mM imidazole, 2 mM EDTA, pH 7.4.
          Applications
          Biological Information
          Biological activity≥90% of C1r will bind with excess C1-INH
          Purity≥90% by SDS-PAGE
          SourcePrepared from serum that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
          Concentration Label Please refer to vial label for lot-specific concentration
          Physicochemical Information
          ContaminantsIgG, IgA, IgM, albumin, C1s, C4BP, C1-INH: ≤trace amounts
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Dry Ice Only
          Toxicity Standard Handling
          Storage ≤ -70°C
          Avoid freeze/thaw Avoid freeze/thaw
          Do not freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          204878

          References

          Reference overview
          Villiers, C.L., et al. 1983. Biochem. J. 215, 369.
          Ziccardi, R.J. and Cooper, N.R. 1976. J. Immunol. 116, 496.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision27-May-2008 RFH
          DescriptionNative, human, activated, C1r complement component. Generally, non-activated form composed of a single-chain glycoprotein. Present in normal human serum at 34 µg/ml. Non-activated C1r is found in circulating blood plasma as a dimer that associates with one C1q molecule and two C1s molecules to form the first component of complement (C1). Ensuing C1q binding to the classical complement pathway activators, each C1r proenzyme monomer is activated by cleavage into two disulfide-linked fragments of M.W. 60,000 and 35,000. The 35,000 peptide contains C1r enzymatic active site. Activated C1r continues activation via the classical pathway by cleaving, and thus activating C1s.
          FormLiquid
          FormulationIn 140 mM NaCl, 10 mM imidazole, 2 mM EDTA, pH 7.4.
          Concentration Label Please refer to vial label for lot-specific concentration
          SourcePrepared from serum that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
          CAS number80295-34-7
          Purity≥90% by SDS-PAGE
          ContaminantsIgG, IgA, IgM, albumin, C1s, C4BP, C1-INH: ≤trace amounts
          Biological activity≥90% of C1r will bind with excess C1-INH
          Storage ≤ -70°C
          Avoid freeze/thaw
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
          Toxicity Standard Handling
          ReferencesVilliers, C.L., et al. 1983. Biochem. J. 215, 369.
          Ziccardi, R.J. and Cooper, N.R. 1976. J. Immunol. 116, 496.