233183 Clodronate, Disodium Salt - CAS 22560-50-5 - Calbiochem

233183
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      CH₂Cl₂O₆P₂Na₂ • 4H₂O 88416-50-6

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      233183-10MG
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          Plastic ampoule 10 mg
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          Description
          OverviewA non-amino, chloro-containing bisphosphonate that acts as a potent inhibitor of osteoclast-mediated bone resorption. It is metabolized into a non-hydrolyzable ATP analog in osteoclasts and macrophages, and induces apoptosis by inhibiting mitochondrial function. An efficient metal chelator that inhibits invasion, adhesion, and migration of PC-3 prostate cancer cells (IC50 = 100 nM).
          Catalogue Number233183
          Brand Family Calbiochem®
          SynonymsClodronate, Disodium, Tetrahydrate, Dichloromethylene-bisphosphonate, Disodium Tetrahydrate
          References
          ReferencesLehenkari, P.P., et al. 2002. Mol. Pharmacol. 61, 1255.
          Virtanen, S.S., et al. 2002. Cancer Res. 62, 2708.
          Smith, R., et al. 1971. Lancet 1, 945.
          Fleisch, H., et al. 1969. Nature 223, 211.
          Product Information
          CAS number88416-50-6
          ATP CompetitiveN
          FormWhite solid
          Hill FormulaCH₂Cl₂O₆P₂Na₂ • 4H₂O
          Chemical formulaCH₂Cl₂O₆P₂Na₂ • 4H₂O
          Hygroscopic Hygroscopic
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetOsteoclast-mediated bone resorption
          Primary Target IC<sub>50</sub>100 nM inhibiting invasion, adhesion, and migration of PC-3 prostate cancer cells
          Purity≥97% by titration
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSSZ7640700
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          233183

          References

          Reference overview
          Lehenkari, P.P., et al. 2002. Mol. Pharmacol. 61, 1255.
          Virtanen, S.S., et al. 2002. Cancer Res. 62, 2708.
          Smith, R., et al. 1971. Lancet 1, 945.
          Fleisch, H., et al. 1969. Nature 223, 211.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision29-April-2008 RFH
          SynonymsClodronate, Disodium, Tetrahydrate, Dichloromethylene-bisphosphonate, Disodium Tetrahydrate
          DescriptionA non-amino, chloro-containing, bisphosphonate that acts as a potent inhibitor of osteoclast-mediated bone resorption. Metabolized to a non-hydrolyzable ATP analog in osteoclasts and macrophages that induces apoptosis by inhibiting mitochondrial function. An efficient metal chelator that inhibits invasion, adhesion and migration of PC-3 prostate cancer cells (IC50 = 100 nM).
          FormWhite solid
          CAS number88416-50-6
          RTECSSZ7640700
          Chemical formulaCH₂Cl₂O₆P₂Na₂ • 4H₂O
          Structure formulaStructure formula
          Purity≥97% by titration
          SolubilityH₂O (1 mg/ml)
          Storage +2°C to +8°C
          Hygroscopic
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          Merck USA index14, 2371
          ReferencesLehenkari, P.P., et al. 2002. Mol. Pharmacol. 61, 1255.
          Virtanen, S.S., et al. 2002. Cancer Res. 62, 2708.
          Smith, R., et al. 1971. Lancet 1, 945.
          Fleisch, H., et al. 1969. Nature 223, 211.