219557 | Cerulenin, Cephalosporium caerulens - CAS 17397-89-6 - Calbiochem

219557
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₂H₁₇NO₃ 17397-89-6

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      219557-5MG
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          Plastic ampoule 5 mg
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          Description
          OverviewAn antifungal antibiotic that inhibits sterol and fatty acid biosynthesis. In fatty acid synthesis, reported to bind in equimolar ratio to β-keto-acyl-ACP synthase. In sterol synthesis, inhibits HMG-CoA synthetase activity. Also shown to inhibit feeding and induce dramatic weight loss in mice.
          Catalogue Number219557
          Brand Family Calbiochem®
          References
          ReferencesLoftus, T.M., et al. 2000. Science 288, 2379.
          Inokashi, J., et al. 1994. Mol. Gen. Genet. 244, 90.
          Schneider, F., et al. 1993. Biochim. Biophys. Acta 1152, 243.
          Product Information
          CAS number17397-89-6
          FormWhite to off-white solid
          Hill FormulaC₁₂H₁₇NO₃
          Chemical formulaC₁₂H₁₇NO₃
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary Targetsterol & fatty acid biosynthesis
          Purity≥98% by TLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSJR1670000
          Safety Information
          R PhraseR: 20/21/22

          Harmful by inhalation, in contact with skin and if swallowed.
          S PhraseS: 36

          Wear suitable protective clothing.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Harmful
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          219557

          References

          Reference overview
          Loftus, T.M., et al. 2000. Science 288, 2379.
          Inokashi, J., et al. 1994. Mol. Gen. Genet. 244, 90.
          Schneider, F., et al. 1993. Biochim. Biophys. Acta 1152, 243.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision28-April-2008 RFH
          DescriptionAn anti-fungal antibiotic that inhibits fatty acid biosynthesis by binding, in equimolar ratio, to β-keto-acyl-ACP synthase. Also inhibits sterol synthesis by blocking the activity of HMG-CoA synthetase activity. Systemic and intracerebroventricular of this compound reduces feeding and induces weight loss.
          FormWhite to off-white solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number17397-89-6
          RTECSJR1670000
          Chemical formulaC₁₂H₁₇NO₃
          Structure formulaStructure formula
          Purity≥98% by TLC
          SolubilityDMSO (10 mg/ml), Ethanol (5 mg/ml) or Acetone
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Harmful
          Merck USA index14, 2004
          ReferencesLoftus, T.M., et al. 2000. Science 288, 2379.
          Inokashi, J., et al. 1994. Mol. Gen. Genet. 244, 90.
          Schneider, F., et al. 1993. Biochim. Biophys. Acta 1152, 243.