219465 | Celastrol, Celastrus scandens - CAS 34157-83-0 - Calbiochem

219465
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₉H₃₈O₄ 34157-83-0

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      219465-10MG
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          Plastic ampoule 10 mg
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          Description
          OverviewA cell-permeable dienone-phenolic triterpene compound that exhibits antioxidant and anti-inflammatory properties. It suppresses LPS-induced pro-inflammatory cytokines release in macrophages and monocytes (IC50 = 40 nM for IL-1β and IL-1α, 80 nM for IL-6, 110 nM for PGE2, and 210 nM for IL-8 and TNF-α), as well as LPS-induced NF-κB activation (IC50 = 270 nM) and NO production (IC50 = 230 nM) in RAW264.7 cells. Preferentially inhibits chymotrypsin-like activity of 20S proteasome with an IC50 of 2.5 µM. Has also been shown to inhibit lipid peroxidation induced by ADP and Fe2+ in rat liver mitochondria (IC50 = 7 µM). Significantly improves the performance in memory, learning, and psychomotor activity in rats. May be useful to minimize inflammation in Alzheimer′s disease (AD).
          Catalogue Number219465
          Brand Family Calbiochem®
          SynonymsTripterin, 3-Hydroxy-24-nor-2-oxo-1(10),3,5,7-friedelatetraen-29-oic Acid, Proteasome Inhibitor XIX
          References
          ReferencesYang, H., et al. 2006. Cancer Res. 66, 4758.
          Westerheide, S.D., et al. 2004. J. Biol. Chem. 279, 56053.
          Jin, H.Z., et al. 2002. J. Nat. Prod. 65, 89.
          Allison, A.C., et al. 2001. Prog. Neuropsychopharmacol. Biol. Psychiatry 25, 1341.
          He, W., et al. 1998. Bioorg. Med. Chem. Lett. 8, 3659.
          Sassa, H., et al. 1990. Biochem. Biophys. Res. Commun. 172, 890.
          Product Information
          CAS number34157-83-0
          ATP CompetitiveN
          FormRed crystals
          Hill FormulaC₂₉H₃₈O₄
          Chemical formulaC₂₉H₃₈O₄
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary Target20S proteasome
          Primary Target IC<sub>50</sub>2.5 µM inhibiting chymotrypsin-like activity of 20S proteasome
          Purity≥95% by TLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          219465

          References

          Reference overview
          Yang, H., et al. 2006. Cancer Res. 66, 4758.
          Westerheide, S.D., et al. 2004. J. Biol. Chem. 279, 56053.
          Jin, H.Z., et al. 2002. J. Nat. Prod. 65, 89.
          Allison, A.C., et al. 2001. Prog. Neuropsychopharmacol. Biol. Psychiatry 25, 1341.
          He, W., et al. 1998. Bioorg. Med. Chem. Lett. 8, 3659.
          Sassa, H., et al. 1990. Biochem. Biophys. Res. Commun. 172, 890.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision05-June-2008 RFH
          SynonymsTripterin, 3-Hydroxy-24-nor-2-oxo-1(10),3,5,7-friedelatetraen-29-oic Acid, Proteasome Inhibitor XIX
          DescriptionA cell-permeable dienone-phenolic triterpene compound with antioxidant and anti-inflammatory properties. It suppresses LPS-induced release of pro-inflammatory cytokines in macrophages and monocytes (IC50 = 40 nM for IL-1β and IL-1α, 80 nM for IL-6, 110 nM for PEG2, and 210 nM for IL-8 and TNF-α). Also suppresses LPS-induced NF-κB activation (IC50 = 270 nM) and NO production (IC50 = 230 nM) in RAW264.7 cells. Preferentially inhibits chymotrypsin-like activity of 20S proteasome with an IC50 of 2.5 µM. Shown to inhibit lipid peroxidation induced by ADP and Fe2+ in rat liver mitochondria (IC50 = 7 µM). Improves performance in memory, learning, and psychomotor activity in rats. May be useful in minimizing inflammation in Alzheimer's disease animal models.
          FormRed crystals
          Intert gas (Yes/No) Packaged under inert gas
          CAS number34157-83-0
          Chemical formulaC₂₉H₃₈O₄
          Structure formulaStructure formula
          Purity≥95% by TLC
          SolubilityDMSO (5 mg/ml) or Ethanol
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesYang, H., et al. 2006. Cancer Res. 66, 4758.
          Westerheide, S.D., et al. 2004. J. Biol. Chem. 279, 56053.
          Jin, H.Z., et al. 2002. J. Nat. Prod. 65, 89.
          Allison, A.C., et al. 2001. Prog. Neuropsychopharmacol. Biol. Psychiatry 25, 1341.
          He, W., et al. 1998. Bioorg. Med. Chem. Lett. 8, 3659.
          Sassa, H., et al. 1990. Biochem. Biophys. Res. Commun. 172, 890.