219498 | Cathepsin S Substrate, Fluorogenic - Calbiochem

219498
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      Overview

      Replacement Information

      Key Specifications Table

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      219498-1MG
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      Stocked 
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          Plastic ampoule 1 mg
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          Description
          OverviewAn internally quenched, highly cathepsin S-selective, fluorogenic peptide substrate that is efficiently cleaved by CatS (kcat/Km = 1.018 µM-1 S-1), but not by Cathepsin B & L (kcat/Km = 0.004 and 0.032 µM-1 S-1, respectively). Studies using CatS-specific inhibitor LHVS reveal that the substrate is not cleaved by other proteolytic enzymes, including CatB, CatH, CatL, and CatX, present in endosomal extracts from human B cell line WT100, dendritic cells, and macrophages. (excitation maximum: 340 nm; emission maximum: 405 nm)
          Catalogue Number219498
          Brand Family Calbiochem®
          SynonymsMca-GRWPPMG~LPWEK(Dnp)-D-R-NH2
          References
          ReferencesLutzner, N., and Kalbacher, H. 2008. J. Biol. Chem. 283, 36185.
          Product Information
          FormYellow solid
          FormulationSupplied as a trifluoroacetate salt.
          Hill FormulaC₉₃H₁₂₃N₂₅O₂₃S
          Chemical formulaC₉₃H₁₂₃N₂₅O₂₃S
          Hygroscopic Hygroscopic
          Applications
          Biological Information
          Purity≥95% by HPLC
          Physicochemical Information
          Peptide SequenceMca-Gly-Arg-Trp-Pro-Pro-Met-Gly~Leu-Pro-Trp-Glu-Lys(Dnp)-D-Arg-NH₂
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped with Blue Ice or with Dry Ice
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          219498

          References

          Reference overview
          Lutzner, N., and Kalbacher, H. 2008. J. Biol. Chem. 283, 36185.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision24-January-2011 RFH
          SynonymsMca-GRWPPMG~LPWEK(Dnp)-D-R-NH2
          DescriptionAn internally quenched, highly cathepsin S-selective, fluorogenic peptide substrate that is efficiently cleaved by CatS (kcat/Km = 1.018 µM-1 S-1), but not by Cathepsin B & L (kcat/Km = 0.004 and 0.032 µM-1 S-1, respectively). Studies using CatS-specific inhibitor LHVS reveal that the substrate is not cleaved by other proteolytic enzymes, including CatB, CatH, CatL, and CatX, present in endosomal extracts from human B cell line WT100, dendritic cells, and macrophages (excitation maximum: 340 nm; emission maximum: 405 nm).
          FormYellow solid
          FormulationSupplied as a trifluoroacetate salt.
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₉₃H₁₂₃N₂₅O₂₃S
          Peptide SequenceMca-Gly-Arg-Trp-Pro-Pro-Met-Gly~Leu-Pro-Trp-Glu-Lys(Dnp)-D-Arg-NH₂
          Purity≥95% by HPLC
          SolubilityDMSO (5 mg/ml)
          Storage -20°C
          Hygroscopic
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesLutzner, N., and Kalbacher, H. 2008. J. Biol. Chem. 283, 36185.