219502 | Cathepsin L Inhibitor, CAA0225 - Calbiochem

219502
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₂₈H₂₉N₃O₅

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      219502-1MG
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      Limited AvailabilityLimited Availability
      Stocked 
      Discontinued
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      Available
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          1 mg
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          Description
          OverviewAn epoxysuccinyl peptide highly selective for rat liver cathepsin L (IC50 = 1.9 nM), while exhibiting little to no effect on rat liver cathepsin B at concentrations higher than 1000-5000 nM, in vitro. During autophagy, it has been shown through immunoblotting that CAA0225 (10 µg/ml) effectively inhibits the degradation of LC3-II and GABARAP compared to control, in nutrient-deprived HeLa and Huh-7 cells.
          Catalogue Number219502
          Brand Family Calbiochem®
          References
          ReferencesTakahashi, K., et al. 2009. Biol. Pharm. Bull. 32, 475.
          Ueno, T., et al. 2009. Autophagy 5, 878.
          Product Information
          FormWhite solid
          Hill FormulaC₂₈H₂₉N₃O₅
          Chemical formulaC₂₈H₂₉N₃O₅
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Purity≥ 95% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped with Blue Ice or with Dry Ice
          Toxicity Standard Handling
          Storage -20°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          219502

          References

          Reference overview
          Takahashi, K., et al. 2009. Biol. Pharm. Bull. 32, 475.
          Ueno, T., et al. 2009. Autophagy 5, 878.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision08-March-2011 RFH
          DescriptionAn epoxysuccinyl peptide highly selective for rat liver cathepsin L (IC50 = 1.9 nM), while exhibiting little to no effect on rat liver cathepsin B at concentrations higher than 1000-5000 nM, in vitro. During autophagy, it has been shown through immunoblotting that CAA0225 (10 µg/ml) effectively inhibits the degradation of LC3-II and GABARAP compared to control, in nutrient-deprived HeLa and Huh-7 cells.
          FormWhite solid
          Chemical formulaC₂₈H₂₉N₃O₅
          Structure formulaStructure formula
          Purity≥ 95% by HPLC
          SolubilityDMSO (100 mg/ml)
          Storage -20°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesTakahashi, K., et al. 2009. Biol. Pharm. Bull. 32, 475.
          Ueno, T., et al. 2009. Autophagy 5, 878.