219402 | Cathepsin L, Human Liver

219402
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      Overview

      Replacement Information

      Key Specifications Table

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      219402-25UG
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      Discontinued
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      Available
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          Glass bottle 25 μg
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          Description
          OverviewNative cathepsin L from human liver. The most potent of the lysosomal proteinases, having a higher activity than cathepsins B and H in the degradation of a variety of physiological protein substrates. Cathepsin L is believed to be responsible for the generation of endostatin from NC1 domain in collagen XVII.
          Note: 1 mU = 1 milliunit.
          Catalogue Number219402
          Brand Family Calbiochem®
          References
          ReferencesKurata, M., et al. 2001. J. Biochem. (Tokyo) 130, 857.
          Ferreras, M., et al. 2000. FEBS Lett. 486, 247.
          Baricos, W.H., et al. 1988. Biochem. J. 252, 301.
          McDonald, J.K., et al. 1988. Biochem. Biophys. Res. Commun. 151, 827.
          Product Information
          Unit of DefinitionOne unit is defined as the amount of enzyme that will hydrolyze 1.0 µmol of Z-FR-AFC per min at 25°C, pH 5.5.
          EC number3.4.22.15
          FormLiquid
          FormulationIn 400 mM NaCl, 20 mM malonate buffer, 1 mM EDTA, pH 5.5.
          Applications
          Biological Information
          SourcePrepared from tissue of individuals that have been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
          Concentration Label Please refer to vial label for lot-specific concentration
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Dry Ice Only
          Toxicity Standard Handling
          Storage ≤ -70°C
          Avoid freeze/thaw Avoid freeze/thaw
          Do not freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          219402

          References

          Reference overview
          Kurata, M., et al. 2001. J. Biochem. (Tokyo) 130, 857.
          Ferreras, M., et al. 2000. FEBS Lett. 486, 247.
          Baricos, W.H., et al. 1988. Biochem. J. 252, 301.
          McDonald, J.K., et al. 1988. Biochem. Biophys. Res. Commun. 151, 827.

          Brochure

          Title
          Cathepsins and Related Products Technical Bulletin
          Proteases Technical Bulletin

          Citations

          Title
        • Moin U Fareed, et al. (2006) Treatment of rats with calpain inhibitors prevents sepsis-induced muscle proteolysis independent of atrogin-1/MAFbx and MuRF1 expression. American Journal of Physiology Regulatory, Integrative and Comparative Physiology 290, R1589-R1597.
        • Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision28-April-2008 RFH
          DescriptionNative cathepsin L from human liver. The most powerful of the lysosomal proteinases, having a higher specific activity than cathepsins B and H in the degradation of a variety of physiological protein substances.
          FormLiquid
          FormulationIn 400 mM NaCl, 20 mM malonate buffer, 1 mM EDTA, pH 5.5.
          Concentration Label Please refer to vial label for lot-specific concentration
          SourcePrepared from tissue of individuals that have been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
          EC number3.4.22.15
          Unit definitionOne unit is defined as the amount of enzyme that will hydrolyze 1.0 µmol of Z-FR-AFC per min at 25°C, pH 5.5.
          Storage ≤ -70°C
          Avoid freeze/thaw
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
          Toxicity Standard Handling
          Merck USA index14, 1905
          ReferencesKurata, M., et al. 2001. J. Biochem. (Tokyo) 130, 857.
          Ferreras, M., et al. 2000. FEBS Lett. 486, 247.
          Baricos, W.H., et al. 1988. Biochem. J. 252, 301.
          McDonald, J.K., et al. 1988. Biochem. Biophys. Res. Commun. 151, 827.
          Citation
        • Moin U Fareed, et al. (2006) Treatment of rats with calpain inhibitors prevents sepsis-induced muscle proteolysis independent of atrogin-1/MAFbx and MuRF1 expression. American Journal of Physiology Regulatory, Integrative and Comparative Physiology 290, R1589-R1597.