219379 Cathepsin K Inhibitor II - Calbiochem

219379
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₃₅H₅₁N₇O₈

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      219379-1MG
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          Plastic ampoule 1 mg
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          Description
          OverviewA cell-permeable peptidyl bis-carbohydrazide compound that acts as a potent, selective, and reversible inhibitor of cathepsin K (Ki,app = 6 nM). Shown to completely block cathepsin K activity in primary human synovial fibroblast cultures at 1 µM. At higher concentrations, also inhibits the activities of cathepsin B and papain (Ki,app = 510 nM, 1.2 µM, respectively). Does not significantly inhibit cathepsin L.
          Catalogue Number219379
          Brand Family Calbiochem®
          SynonymsInhibitor Boc-I, 1-(N-Benzyloxycarbonyl-leucyl)-5-(N-Boc-phenylalanyl-leucyl)carbohydrazide, Z-L-NHNHCONHNH-LF-Boc
          References
          ReferencesWang, D., et al. 2002. Biochemistry 41, 8849.
          Product Information
          ATP CompetitiveN
          FormLyophilized white solid
          Hill FormulaC₃₅H₅₁N₇O₈
          Chemical formulaC₃₅H₅₁N₇O₈
          ReversibleY
          Applications
          Biological Information
          Primary Targetcathepsin K
          Primary Target K<sub>i</sub>6 nM against cathepsin; 510 nM, 1.2 µM, against cathepsin B and papain, respectively
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableY
          Peptide SequenceBoc-Phe-Leu-NHNH-CO-NHNH-Leu-Z
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Blue Ice Only
          Toxicity Standard Handling
          Storage -20°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          219379

          References

          Reference overview
          Wang, D., et al. 2002. Biochemistry 41, 8849.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision05-June-2008 RFH
          SynonymsInhibitor Boc-I, 1-(N-Benzyloxycarbonyl-leucyl)-5-(N-Boc-phenylalanyl-leucyl)carbohydrazide, Z-L-NHNHCONHNH-LF-Boc
          DescriptionA cell-permeable peptidyl bis-carbohydrazide compound that acts as a potent, selective, and reversible inhibitor of cathepsin K (Ki = 6 nM). Reported to completely block cathepsin K activity in primary human synovial fibroblast cultures at a concentration of 1 µM. Also shown to inhibit the activity of cathepsin B and papain at higher concentrations (Ki = 510 nM and 1.2 µM, respectively). Does not significantly inhibit cathepsin L.
          FormLyophilized white solid
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₃₅H₅₁N₇O₈
          Peptide SequenceBoc-Phe-Leu-NHNH-CO-NHNH-Leu-Z
          Purity≥95% by HPLC
          SolubilityDMSO (1 mg/ml)
          Storage -20°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Standard Handling
          ReferencesWang, D., et al. 2002. Biochemistry 41, 8849.