219401 | Cathepsin D, Human Liver

219401
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      Overview

      Replacement Information

      Key Specifications Table

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      219401-15U
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          Plastic ampoule 15 u
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          219401-30U
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              Plastic ampoule 30 u
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              Description
              OverviewNative cathepsin D from human liver. A major lysosomal aspartyl protease produced as a 52 kDa proenzyme. Overexpression of cathepsin D in human breast cancers is associated with higher risk of relapse and metastasis. Cathepsin D degrades extracellular matrix and releases growth factors bound to the matrix.
              Catalogue Number219401
              Brand Family Calbiochem®
              References
              ReferencesBerchem, G., et al. 2002. Oncogene 21, 5951.
              Barbi, G.P., et al. 1994. Oncology 51, 329.
              Krishnan, V., et al. 1994. J. Biol. Chem. 269, 15912.
              Touitou, I., et al. 1994. Eur. J. Cancer 30A, 390.
              Rijnboutt, S., et al. 1991. J. Biol. Chem. 266, 23586.
              Johnson, G.V., et al. 1991. J. Neurochem. 57, 1577.
              Erickson, A. 1989. J. Cell. Biochem. 40, 31.
              Product Information
              CAS number9025-26-7
              Unit of DefinitionOne unit is defined as the amount of enzyme that will digest acid-denatured hemoglobin in 60 min, at 37°C, pH 3.3, releasing peptides soluble in 10% TCA, as measured by an increase in absorbance of 1.0 at 280 nm
              EC number3.4.23.5
              FormLyophilized
              FormulationLyophilized from 2 mM sodium phosphate buffer, pH 6.5.
              Applications
              Biological Information
              Purity≥90% by SDS-PAGE
              SourcePrepared from tissue of individuals that have been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
              Specific Activity≥300 units/mg protein
              Physicochemical Information
              Dimensions
              Materials Information
              Toxicological Information
              Safety Information according to GHS
              Safety Information
              Product Usage Statements
              Storage and Shipping Information
              Ship Code Ambient Temperature Only
              Toxicity Standard Handling
              Storage -20°C
              Do not freeze Ok to freeze
              Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C) for long term storage or refrigerate (4°C) for short term storage. Stock solutions are stable for up to 1 week at 4°C. Keep on ice when working with material. When product is brought to its active pH (3.3), autolysis occurs.
              Packaging Information
              Transport Information
              Supplemental Information
              Specifications

              Documentation

              SDS

              Title

              Safety Data Sheet (SDS) 

              Certificates of Analysis

              TitleLot Number
              219401

              References

              Reference overview
              Berchem, G., et al. 2002. Oncogene 21, 5951.
              Barbi, G.P., et al. 1994. Oncology 51, 329.
              Krishnan, V., et al. 1994. J. Biol. Chem. 269, 15912.
              Touitou, I., et al. 1994. Eur. J. Cancer 30A, 390.
              Rijnboutt, S., et al. 1991. J. Biol. Chem. 266, 23586.
              Johnson, G.V., et al. 1991. J. Neurochem. 57, 1577.
              Erickson, A. 1989. J. Cell. Biochem. 40, 31.

              Brochure

              Title
              Cathepsins and Related Products Technical Bulletin
              Proteases Technical Bulletin
              Data Sheet

              Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

              Revision28-April-2008 RFH
              DescriptionNative cathepsin D from human liver. Degrades the extracellular matrix and releases growth factors bound to the matrix. Overexpression of cathepsin D in human breast cancers is associated with a higher risk of relapse and metastasis.
              FormLyophilized
              FormulationLyophilized from 2 mM sodium phosphate buffer, pH 6.5.
              SourcePrepared from tissue of individuals that have been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
              CAS number9025-26-7
              EC number3.4.23.5
              Purity≥90% by SDS-PAGE
              Specific activity≥300 units/mg protein
              Unit definitionOne unit is defined as the amount of enzyme that will digest acid-denatured hemoglobin in 60 min, at 37°C, pH 3.3, releasing peptides soluble in 10% TCA, as measured by an increase in absorbance of 1.0 at 280 nm
              SolubilitySterile H₂O or aqueous buffers. Please see vial label for lot-specific reconstitution volume.
              Storage -20°C
              Do Not Freeze Ok to freeze
              Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C) for long term storage or refrigerate (4°C) for short term storage. Stock solutions are stable for up to 1 week at 4°C. Keep on ice when working with material. When product is brought to its active pH (3.3), autolysis occurs.
              Toxicity Standard Handling
              Merck USA index14, 1905
              ReferencesBerchem, G., et al. 2002. Oncogene 21, 5951.
              Barbi, G.P., et al. 1994. Oncology 51, 329.
              Krishnan, V., et al. 1994. J. Biol. Chem. 269, 15912.
              Touitou, I., et al. 1994. Eur. J. Cancer 30A, 390.
              Rijnboutt, S., et al. 1991. J. Biol. Chem. 266, 23586.
              Johnson, G.V., et al. 1991. J. Neurochem. 57, 1577.
              Erickson, A. 1989. J. Cell. Biochem. 40, 31.