218825 | Caspase Inhibitor Set IV - Calbiochem

218825
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      Overview

      Replacement Information

      Key Specifications Table

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      218825-1SET
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      Stocked 
      Discontinued
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      Available
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          Will advise
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          Glass bottle 1 set
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          Description
          OverviewA set of four ready-to-use cell-permeable, irreversible inhibitors of various caspase-family proteases and a negative control apoptosis inducer. Each vial contains 25 µl of a 10 mM solution in DMSO of Caspase-3 Inhibitor II, Z-DEVD-FMK (Cat. No. 264155); Caspase-8 Inhibitor II, Z-IETD-FMK (Cat. No. 218759); Caspase-9 Inhibitor I, Z-LEHD-FMK (Cat. No 218761); general caspase inhibitor, Z-VAD-FMK (Cat. No. 627610); the negative control Z-FA-FMK (Cat. No. 342000), and an aqueous solution (100 µl, 6.1 µg/µl) of an apoptosis inducer, Doxorubicin, Hydrochloride (Cat. No. 324380). Supplied with a data sheet.
          Catalogue Number218825
          Brand Family Calbiochem®
          References
          Product Information
          ATP CompetitiveN
          FormLiquid
          ReversibleN
          Applications
          Biological Information
          Primary Targetpan-caspase
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          R PhraseR: 36/38-45-46

          Irritating to eyes and skin.
          May cause cancer.
          May cause heritable genetic damage.
          S PhraseS: 26-36/37-45-53-23-28

          In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
          Wear suitable protective clothing and gloves.
          In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
          Avoid exposure - obtain special instructions before use.
          Do not breathe fumes.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Multiple Toxicity Values, refer to MSDS
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          218825
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision26-April-2010 RFH
          DescriptionApoptosis is a normal process in development and morphogenesis. Many cells can be activated to undergo apoptosis following the interaction of selected ligands with cell surface receptors. Receptor-mediated apoptosis involves the activation of caspases (cysteine-containing aspartate-specific proteases). A distinctive feature of caspases is the requirement of an aspartic acid residue in the substrate P1 position.

          Caspase inhibitors act by binding to the active site of caspases and form either a reversible or an irreversible linkage. Caspase inhibitor design includes a peptide recognition sequence attached to a functional group such as an aldehyde (CHO), chloromethylketone (CMK), fluoromethylketone (FMK), or fluoroacyloxymethylketone (FAOM). Caspase inhibitors with a CHO group are reversible and those with a CMK, FMK, or FAOM group are irreversible and cell-permeable. FMK exhibits slightly less reactivity than CMK and therefore is more specific for the enzyme being inhibited.
          FormLiquid
          Intert gas (Yes/No) Packaged under inert gas
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Toxicity Multiple Toxicity Values, refer to MSDS