218806 | Caspase Inhibitor Set III - Calbiochem

218806
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      Overview

      Replacement Information

      Key Specifications Table

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      218806-1SET
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      Limited AvailabilityLimited Availability
      Stocked 
      Discontinued
      Limited Quantities Available
      Available
        Remaining : Will advise
          Remaining : Will advise
          Will advise
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          Glass bottle 1 set
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          Description
          OverviewA set of eight ready to use cell-permeable, irreversible inhibitors of various caspase-family proteases. Contains 25 µl (2 mM) each of Caspase-1 Inhibitor VI, Z-YVAD-FMK (Cat. No. 218746); Caspase-2 Inhibitor I, Z-VDVAD-FMK (Cat. No. 218744); Caspase-3 Inhibitor II, Z-DEVD-FMK (Cat. No. 264155); Caspase-5 Inhibitor I, Z-WEHD-FMK (Cat. No. 218753); Caspase-6 Inhibitor I, Z-VEID-FMK (Cat. No. 218757); Caspase-8 Inhibitor II, Z-IETD-FMK (Cat. No. 218759); Caspase-9 Inhibitor I, Z-LEHD-FMK (Cat. No. 218761); and Caspase Inhibitor I, Z-VAD-FMK (Cat. No. 627610). Supplied with a data sheet.
          Catalogue Number218806
          Brand Family Calbiochem®
          References
          ReferencesHumke, E.W., et al. 1998. J. Biol. Chem. 273, 15702.
          Datta, R., et al. 1997. J. Biol. Chem. 272, 1965.
          Martin, L.M., et al. 1997. J. Biol. Chem. 272, 7421.
          Takahashi, A., et al. 1997. Exp. Cell Res. 231, 123.
          Talanian, R.V., et al. 1997. J. Biol. Chem. 272, 9677.
          Thornberry, N.A., et al. 1997. J. Biol. Chem. 272, 17907.
          Nicholson, D.W., et al. 1995. Nature 376, 37.
          Thornberry, N.A., et al. 1992. Nature 356, 768.
          Product Information
          FormLiquid
          FormulationSupplied as 2 mM in DMSO.
          ReversibleN
          Applications
          Biological Information
          Primary TargetCaspase-1, caspase-2, caspase-3, caspase-4, caspase-5, caspase-6, caspase-7, caspase-8
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          R PhraseR: 36/38

          Irritating to eyes and skin.
          S PhraseS: 26

          In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Blue Ice Only
          Toxicity Irritant
          Storage -20°C
          Protect from Moisture Protect from moisture
          Do not freeze Ok to freeze
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          218806

          References

          Reference overview
          Humke, E.W., et al. 1998. J. Biol. Chem. 273, 15702.
          Datta, R., et al. 1997. J. Biol. Chem. 272, 1965.
          Martin, L.M., et al. 1997. J. Biol. Chem. 272, 7421.
          Takahashi, A., et al. 1997. Exp. Cell Res. 231, 123.
          Talanian, R.V., et al. 1997. J. Biol. Chem. 272, 9677.
          Thornberry, N.A., et al. 1997. J. Biol. Chem. 272, 17907.
          Nicholson, D.W., et al. 1995. Nature 376, 37.
          Thornberry, N.A., et al. 1992. Nature 356, 768.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision04-January-2008 RFH
          DescriptionApoptosis is a normal process in development and morphogenesis. Many cells can be activated to undergo apoptosis following the interaction of selected ligands with cell surface receptors. Receptor-mediated apoptosis involves the activation of caspases (cysteine-containing aspartate-specific proteases). A distinctive feature of caspases is the requirement of an aspartic acid residue in the substrate P1 position.

          Caspase inhibitors act by binding to the active site of caspases and form either a reversible or an irreversible linkage. Caspase inhibitor design includes a peptide recognition sequence attached to a functional group such as an aldehyde (CHO), chloromethylketone (CMK), fluoromethylketone (FMK), or fluoroacyloxymethylketone (FAOM). Caspase inhibitors with a CHO group are reversible and those with a CMK, FMK, or FAOM group are irreversible and cell-permeable. FMK exhibits slightly less reactivity than CMK and therefore is more specific for the enzyme being inhibited.
          FormLiquid
          FormulationSupplied as 2 mM in DMSO.
          Storage -20°C
          Protect from moisture
          Do Not Freeze Ok to freeze
          Toxicity Irritant
          ReferencesHumke, E.W., et al. 1998. J. Biol. Chem. 273, 15702.
          Datta, R., et al. 1997. J. Biol. Chem. 272, 1965.
          Martin, L.M., et al. 1997. J. Biol. Chem. 272, 7421.
          Takahashi, A., et al. 1997. Exp. Cell Res. 231, 123.
          Talanian, R.V., et al. 1997. J. Biol. Chem. 272, 9677.
          Thornberry, N.A., et al. 1997. J. Biol. Chem. 272, 17907.
          Nicholson, D.W., et al. 1995. Nature 376, 37.
          Thornberry, N.A., et al. 1992. Nature 356, 768.