218753 | Caspase-5 Inhibitor I

218753
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₃₇H₄₂FN₇O₁₀

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      218753-1MG
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          Plastic ampoule 1 mg
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          218753-250UG
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              Plastic ampoule 250 μg
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              Description
              OverviewA potent, cell-permeable, and irreversible inhibitor of caspase-5. Strongly inhibits caspase-1. Also inhibits caspase-4 and caspase-8.
              Catalogue Number218753
              Brand Family Calbiochem®
              SynonymsZ-WE(OMe)HD(OMe)-FMK
              References
              ReferencesGarcia-Calvo, M., et al. 1998. J. Biol. Chem. 273, 32608.
              Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
              Rano, T., et al. 1997. Chem. Biol. 4, 149.
              Product Information
              FormWhite solid
              FormulationSupplied as a trifluoroacetate salt.
              Hill FormulaC₃₇H₄₂FN₇O₁₀
              Chemical formulaC₃₇H₄₂FN₇O₁₀
              ReversibleN
              Applications
              Biological Information
              Primary Targetcaspase-1, caspase-4, caspase-5, caspase-8
              Puritysingle spot by TLC
              Physicochemical Information
              Cell permeableY
              Peptide SequenceZ-Trp-Glu(OMe)-His-Asp(OMe)-CH₂F*
              Dimensions
              Materials Information
              Toxicological Information
              Safety Information according to GHS
              Safety Information
              Product Usage Statements
              Storage and Shipping Information
              Ship Code Ambient Temperature Only
              Toxicity Standard Handling
              Storage -20°C
              Protect from Moisture Protect from moisture
              Do not freeze Ok to freeze
              Special InstructionsFollowing reconstitution, refrigerate (4°C). Stock solutions are stable for up to 4 months at 4°C.
              Packaging Information
              Transport Information
              Supplemental Information
              Specifications

              Documentation

              SDS

              Title

              Safety Data Sheet (SDS) 

              Certificates of Analysis

              TitleLot Number
              218753

              References

              Reference overview
              Garcia-Calvo, M., et al. 1998. J. Biol. Chem. 273, 32608.
              Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
              Rano, T., et al. 1997. Chem. Biol. 4, 149.
              Data Sheet

              Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

              Revision02-June-2008 JSW
              SynonymsZ-WE(OMe)HD(OMe)-FMK
              DescriptionA potent, cell-permeable and irreversible inhibitor of caspase-5 (ICErel-III, TY), as well as caspase-1 and caspase-4.
              FormWhite solid
              FormulationSupplied as a trifluoroacetate salt.
              Chemical formulaC₃₇H₄₂FN₇O₁₀
              Peptide SequenceZ-Trp-Glu(OMe)-His-Asp(OMe)-CH₂F*
              Puritysingle spot by TLC
              SolubilityDMSO (5 mg/ml)
              Storage -20°C
              Protect from moisture
              Do Not Freeze Ok to freeze
              Special InstructionsFollowing reconstitution, refrigerate (4°C). Stock solutions are stable for up to 4 months at 4°C.
              Toxicity Standard Handling
              ReferencesGarcia-Calvo, M., et al. 1998. J. Biol. Chem. 273, 32608.
              Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
              Rano, T., et al. 1997. Chem. Biol. 4, 149.