264151 | Caspase-3 Substrate VII, Fluorogenic - Calbiochem

264151
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      Overview

      Replacement Information

      Key Specifications Table

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      264151-1MG
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      Stocked 
      Discontinued
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      Available
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          Plastic ampoule 1 mg
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          264151-5MG
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          Limited AvailabilityLimited Availability
          Stocked 
          Discontinued
          Limited Quantities Available
          Available
            Remaining : Will advise
              Remaining : Will advise
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              Plastic ampoule 5 mg
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              Description
              OverviewFluorogenic caspase-3 substrate. Also acts as a substrate for granzyme B-processed caspase-6, caspase-7, caspase-8, and caspase-10.
              Catalogue Number264151
              Brand Family Calbiochem®
              SynonymsAc-DEVD-AFC
              References
              ReferencesKeramaris, E., et al. 2000. Mol. Cell Neurosci. 15, 368.
              Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
              Product Information
              ATP CompetitiveN
              FormWhite lyophilized solid
              Hill FormulaC₃₀H₃₄F₃N₅O₁₃
              Chemical formulaC₃₀H₃₄F₃N₅O₁₃
              ReversibleN
              Applications
              Biological Information
              Primary TargetFluorogenic caspase-3 substrate
              Purity≥95% by HPLC
              Physicochemical Information
              Cell permeableN
              Emission max.
              Excitation max.
              Peptide SequenceAc-Asp-Glu-Val-Asp-AFC
              Dimensions
              Materials Information
              Toxicological Information
              Safety Information according to GHS
              Safety Information
              Product Usage Statements
              Storage and Shipping Information
              Ship Code Ambient Temperature Only
              Toxicity Standard Handling
              Storage -20°C
              Protect from Light Protect from light
              Protect from Moisture Protect from moisture
              Do not freeze Ok to freeze
              Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
              Packaging Information
              Transport Information
              Supplemental Information
              Specifications

              Documentation

              SDS

              Title

              Safety Data Sheet (SDS) 

              Certificates of Analysis

              TitleLot Number
              264151

              References

              Reference overview
              Keramaris, E., et al. 2000. Mol. Cell Neurosci. 15, 368.
              Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.

              Citations

              Title
            • Yumin Zhang, et al. (2004) Peroxynitrite-Induced Neuronal Apoptosis is Mediated by Intracellular Zinc Release and 12-Lipoxygenase Activation. Journal of Neuroscience 24, 10616-10627.
            • Data Sheet

              Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

              Revision15-June-2008 RFH
              SynonymsAc-DEVD-AFC
              DescriptionFluorogenic caspase-3 substrate (excitation maximum: ~400 nm; emission maximum: ~505 nm). Also acts as a substrate for granzyme B-processed ICE-LAP3, caspase-6, caspase-7, caspase-8, and caspase-10.
              FormWhite lyophilized solid
              Chemical formulaC₃₀H₃₄F₃N₅O₁₃
              Peptide SequenceAc-Asp-Glu-Val-Asp-AFC
              Purity≥95% by HPLC
              SolubilityDMSO (5 mg/ml)
              Storage -20°C
              Protect from moisture
              Protect from light
              Do Not Freeze Ok to freeze
              Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
              Toxicity Standard Handling
              ReferencesKeramaris, E., et al. 2000. Mol. Cell Neurosci. 15, 368.
              Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
              Citation
            • Yumin Zhang, et al. (2004) Peroxynitrite-Induced Neuronal Apoptosis is Mediated by Intracellular Zinc Release and 12-Lipoxygenase Activation. Journal of Neuroscience 24, 10616-10627.