219012 Caspase-3 Inhibitor VII - CAS 745046-84-8 - Calbiochem

219012
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₀H₂₁N₃O₇S 745046-84-8

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      219012-10MG
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          Plastic ampoule 10 mg
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          Description
          OverviewA cell-permeable, non-peptidyl pyrroloquinoline compound that acts as a potent, reversible, and non-competitive inhibitor of caspase-3 (IC50 = 23 nM) with 10-100-fold greater selectivity. Shown to display higher anti-apoptotic activity than Z-VAD-FMK (Cat. No. 627610) in a model of Staurosporine- (Cat. No. 569397) induced apoptosis in human Jurkat T cells.
          Catalogue Number219012
          Brand Family Calbiochem®
          Synonyms2-(4-Methyl-8-(morpholin-4-ylsulfonyl)-1,3-dioxo-1,3-dihydro-2H-pyrrolo[3,4-c]quinolin-2-yl)ethyl acetate
          References
          ReferencesKravchenko, D.V., et al. 2005. J. Med. Chem. 48, 3680.
          Product Information
          CAS number745046-84-8
          ATP CompetitiveN
          FormOff-white solid
          Hill FormulaC₂₀H₂₁N₃O₇S
          Chemical formulaC₂₀H₂₁N₃O₇S
          ReversibleY
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary Targetcapase-3
          Primary Target IC<sub>50</sub>23 nM
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          219012

          References

          Reference overview
          Kravchenko, D.V., et al. 2005. J. Med. Chem. 48, 3680.

          Brochure

          Title
          Biologics 32.3 PDF ( 927 KB )
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision05-April-2011 RFH
          Synonyms2-(4-Methyl-8-(morpholin-4-ylsulfonyl)-1,3-dioxo-1,3-dihydro-2H-pyrrolo[3,4-c]quinolin-2-yl)ethyl acetate
          DescriptionA cell-permeable, non-peptidyl pyrroloquinoline compound that acts as a potent, reversible, and non-competitive inhibitor of caspase-3 (IC50 = 23 nM) with larger than 10-fold greater selectivity towards caspase-3 than caspases-1, -2, and -4 through -10. Shown to display higher anti-apoptotic activity than Z-VAD-FMK (Cat. No. 627610) in preventing Staurosporine- (Cat. No. 569397) induced apoptosis in human Jurkat T cells.
          FormOff-white solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number745046-84-8
          Chemical formulaC₂₀H₂₁N₃O₇S
          Structure formulaStructure formula
          Purity≥95% by HPLC
          SolubilityDMSO (10 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesKravchenko, D.V., et al. 2005. J. Med. Chem. 48, 3680.