264155 | Caspase-3 Inhibitor II - CAS 210344-95-9 - Calbiochem

264155
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₃₀H₄₁FN₄O₁₂ 210344-95-9

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      264155-1MG
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          Plastic ampoule 1 mg
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          264155-250UG
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              Plastic ampoule 250 μg
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              Description
              OverviewA potent, cell-permeable, and irreversible inhibitor of caspase-3 as well as caspase-6, caspase-7, caspase-8, and caspase-10. When using with purified native or recombinant enzyme, pretreatment with an esterase is required. A 5 mM (250 µg/75 µl) solution of Z-DEVD-FMK (Cat. No. 264156) in DMSO is also available.
              Catalogue Number264155
              Brand Family Calbiochem®
              SynonymsZ-D(OMe)E(Ome)VD(OMe)-FMK
              References
              ReferencesThornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
              Masuda, Y., et al. 1997. Biochem. Biophys. Res. Commun. 234, 641.
              Nicholson, D.W. 1996. Nature Biotech. 14, 297.
              Schlegel, J., et al. 1996. J. Biol. Chem. 271, 1841.
              Nicholson, D.W., et al. 1995. Nature 376, 37.
              Product Information
              CAS number210344-95-9
              ATP CompetitiveN
              FormWhite to slightly brown solid
              Hill FormulaC₃₀H₄₁FN₄O₁₂
              Chemical formulaC₃₀H₄₁FN₄O₁₂
              ReversibleN
              Structure formula ImageStructure formula Image
              Applications
              ApplicationCaspase-3 Inhibitor II, CAS 210344-95-9, is a cell-permeable, potent, and irreversible inhibitor of caspase-3 (IC50 = 130 nM). Also inhibits caspase-6, caspase-7, caspase-8, and caspase-10.
              Biological Information
              Primary Targetcaspase-3, caspase-6, caspase-7, caspase-8, caspase-10
              Purity≥90% by TLC
              Physicochemical Information
              Cell permeableY
              Peptide SequenceZ-Asp(OCH₃)-Glu(OCH₃)-Val-Asp(OCH₃)-FMK
              Dimensions
              Materials Information
              Toxicological Information
              Safety Information according to GHS
              Safety Information
              Product Usage Statements
              Storage and Shipping Information
              Ship Code Ambient Temperature Only
              Toxicity Standard Handling
              Storage -20°C
              Protect from Moisture Protect from moisture
              Do not freeze Ok to freeze
              Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
              Packaging Information
              Transport Information
              Supplemental Information
              Specifications

              Documentation

              SDS

              Title

              Safety Data Sheet (SDS) 

              Certificates of Analysis

              TitleLot Number
              264155

              References

              Reference overview
              Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
              Masuda, Y., et al. 1997. Biochem. Biophys. Res. Commun. 234, 641.
              Nicholson, D.W. 1996. Nature Biotech. 14, 297.
              Schlegel, J., et al. 1996. J. Biol. Chem. 271, 1841.
              Nicholson, D.W., et al. 1995. Nature 376, 37.

              Citations

              Title
            • Heui-Young Ryu, et al. (2005) Environmental Chemical-Induced Bone Marrow B Cell Apoptosis: Death Receptor-Independent Activation of a Caspase-3 to Caspase-8 Pathway. Molecular Pharmacology 68, 1087-1096.
            • Data Sheet

              Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

              Revision31-March-2011 RFH
              SynonymsZ-D(OMe)E(Ome)VD(OMe)-FMK
              DescriptionA potent, cell-permeable and irreversible inhibitor of CPP-32/apopain, a member of the ICE/CED-3 family of cysteine proteases.
              FormWhite to slightly brown solid
              CAS number210344-95-9
              Chemical formulaC₃₀H₄₁FN₄O₁₂
              Peptide SequenceZ-Asp(OCH₃)-Glu(OCH₃)-Val-Asp(OCH₃)-FMK
              Structure formulaStructure formula
              Purity≥90% by TLC
              SolubilityDMSO (5 mg/ml)
              Storage -20°C
              Protect from moisture
              Do Not Freeze Ok to freeze
              Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
              Toxicity Standard Handling
              ReferencesThornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
              Masuda, Y., et al. 1997. Biochem. Biophys. Res. Commun. 234, 641.
              Nicholson, D.W. 1996. Nature Biotech. 14, 297.
              Schlegel, J., et al. 1996. J. Biol. Chem. 271, 1841.
              Nicholson, D.W., et al. 1995. Nature 376, 37.
              Citation
            • Heui-Young Ryu, et al. (2005) Environmental Chemical-Induced Bone Marrow B Cell Apoptosis: Death Receptor-Independent Activation of a Caspase-3 to Caspase-8 Pathway. Molecular Pharmacology 68, 1087-1096.