400010 | Caspase-1 Inhibitor I - CAS 143313-51-3 - Calbiochem

400010
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₃H₃₂N₄O₈ 143313-51-3

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      400010-1MG
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          Plastic ampoule 1 mg
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          400010-5MG
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              Plastic ampoule 5 mg
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              Description
              OverviewA potent, specific, and reversible inhibitor of caspase-1 (Ki = 200 pM for human recombinant caspase-1), caspase-4, and caspase-5. Strongly inhibits anti-APO-1 induced apoptosis in L929-APO-1 cells.
              Catalogue Number400010
              Brand Family Calbiochem®
              SynonymsIL-1β Converting Enzyme (ICE) Inhibitor I, Ac-YVAD-CHO, L-709049
              References
              ReferencesGarcia-Calvo, M., et al. 1998. J. Biol. Chem. 273, 32608.
              Hilbi, H., et al. 1998. J. Biol. Chem. 273, 32895.
              Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
              Los, M., et al. 1995. Nature 375, 81.
              Walker, N.P.C., et al. 1994. Cell 78, 343.
              Wilson, K.P., et al. 1994. Nature 370, 270.
              Thornberry, N.A., et al. 1992. Nature 356, 768.
              Product Information
              CAS number143313-51-3
              ATP CompetitiveN
              FormWhite powder
              Hill FormulaC₂₃H₃₂N₄O₈
              Chemical formulaC₂₃H₃₂N₄O₈
              ReversibleY
              Structure formula ImageStructure formula Image
              Applications
              Biological Information
              Primary Targetcaspase-1, human recombinant
              Primary Target K<sub>i</sub>200 pM for human recombinant caspase-1
              Purity≥97% by HPLC
              Physicochemical Information
              Cell permeableN
              Peptide SequenceAc-Tyr-Val-Ala-Asp-CHO
              Dimensions
              Materials Information
              Toxicological Information
              Safety Information according to GHS
              Safety Information
              Product Usage Statements
              Storage and Shipping Information
              Ship Code Ambient Temperature Only
              Toxicity Standard Handling
              Storage -20°C
              Protect from Light Protect from light
              Do not freeze Ok to freeze
              Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
              Packaging Information
              Transport Information
              Supplemental Information
              Specifications

              Documentation

              SDS

              Title

              Safety Data Sheet (SDS) 

              Certificates of Analysis

              TitleLot Number
              400010

              References

              Reference overview
              Garcia-Calvo, M., et al. 1998. J. Biol. Chem. 273, 32608.
              Hilbi, H., et al. 1998. J. Biol. Chem. 273, 32895.
              Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
              Los, M., et al. 1995. Nature 375, 81.
              Walker, N.P.C., et al. 1994. Cell 78, 343.
              Wilson, K.P., et al. 1994. Nature 370, 270.
              Thornberry, N.A., et al. 1992. Nature 356, 768.
              Data Sheet

              Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

              Revision17-July-2014 JSW
              SynonymsIL-1β Converting Enzyme (ICE) Inhibitor I, Ac-YVAD-CHO, L-709049
              DescriptionInterleukin-1β converting enzyme (ICE) is a cysteine protease that cleaves the IL-1β precursor to mature IL-1β. ICE inhibitor I is a potent, specific, and reversible inhibitor of ICE (Ki = 200 pM for human recombinant ICE). Strongly inhibits anti-APO-1 induced apoptosis in L929-APO-1 cells.
              FormWhite powder
              CAS number143313-51-3
              Chemical formulaC₂₃H₃₂N₄O₈
              Peptide SequenceAc-Tyr-Val-Ala-Asp-CHO
              Structure formulaStructure formula
              Purity≥97% by HPLC
              SolubilityDMSO (5 mg/ml) or H₂O
              Storage -20°C
              Protect from light
              Do Not Freeze Ok to freeze
              Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
              Toxicity Standard Handling
              ReferencesGarcia-Calvo, M., et al. 1998. J. Biol. Chem. 273, 32608.
              Hilbi, H., et al. 1998. J. Biol. Chem. 273, 32895.
              Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
              Los, M., et al. 1995. Nature 375, 81.
              Walker, N.P.C., et al. 1994. Cell 78, 343.
              Wilson, K.P., et al. 1994. Nature 370, 270.
              Thornberry, N.A., et al. 1992. Nature 356, 768.

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              Categories

              Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Apoptosis/Necrosis Inhibitors > Caspase Inhibitors