218850 | Casein Kinase I Inhibitor V, LH846 - CAS 639052-78-2 - Calbiochem

218850
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₆H₁₃ClN₂OS 639052-78-2

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      218850-10MG
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          Glass bottle 10 mg
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          Description
          OverviewA cell-permeable benzothiazolo compound that acts a potent, selective, and reversible inhibitor of CKIδ (IC50 = 290 nM). Exhibits much reduced potency towards CKIε and CKIα isoforms (IC50 =1.3 and 2.5 µM, respectively). Does not affect the activity of CK2 or other kinases in a 59-protein kinase panel. Shown to block CKIδ-dependent period protein PER1 phosphorylation and diminish its proteasomal degradation in a dose-dependent manner. Also, shown to lengthen the circadian period in U2OS cells (10 h at 8 µM) without significantly affecting the amplitude of Per2-dLuc and Bmal1-dLuc rhythms.
          Catalogue Number218850
          Brand Family Calbiochem®
          SynonymsN-(5-Chloro-6-methylbenzo[d]thiazol-2-yl)-2-phenylacetamide, N-(5-Chloro-6-methyl-1,3-benzothiazol-2-yl)-2-phenylacetamide
          References
          ReferencesLee, J.W., et al. 2011. Angew. Chem. Int. Ed. 50, 10608.
          Product Information
          CAS number639052-78-2
          FormLight yellow powder
          Hill FormulaC₁₆H₁₃ClN₂OS
          Chemical formulaC₁₆H₁₃ClN₂OS
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Purity≥98% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          218850

          References

          Reference overview
          Lee, J.W., et al. 2011. Angew. Chem. Int. Ed. 50, 10608.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision09-December-2013 JSW
          SynonymsN-(5-Chloro-6-methylbenzo[d]thiazol-2-yl)-2-phenylacetamide, N-(5-Chloro-6-methyl-1,3-benzothiazol-2-yl)-2-phenylacetamide
          DescriptionA cell-permeable benzothiazolo compound that acts a potent, selective, and reversible inhibitor of CKIδ (IC50 = 290 nM). Exhibits much reduced potency towards CKIε and CKIα isoforms (IC50 =1.3 and 2.5 µM, respectively). Does not affect the activity of CK2 or other kinases in a 59-protein kinase panel. Shown to block CKIδ-dependent period protein PER1 phosphorylation and diminish its proteasomal degradation in a dose-dependent manner. Also, shown to lengthen the circadian period in U2OS cells (10 h at 8 µM) without significantly affecting the amplitude of Per2-dLuc and Bmal1-dLuc rhythms.
          FormLight yellow powder
          Intert gas (Yes/No) Packaged under inert gas
          CAS number639052-78-2
          Chemical formulaC₁₆H₁₃ClN₂OS
          Structure formulaStructure formula
          Purity≥98% by HPLC
          SolubilityDMSO (50 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesLee, J.W., et al. 2011. Angew. Chem. Int. Ed. 50, 10608.