218716 | Casein Kinase I Inhibitor II, PF-670462 - CAS 950912-80-8 - Calbiochem

218716
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₉H₂₀FN₅ • 2HCl 950912-80-8

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      218716-5MG
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          Glass bottle 5 mg
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          Description
          OverviewA cell-permeable tri-substituted imidazole compound that acts as a potent and reversible inhibitor of casein kinase Iε/δ (IC50 = 7.7 and 14 nM, respectively) with modest to excellent selectivity over EGFR and p38 MAPK (IC50 = 150 and 190 nM, respectively) and over 43 related kinases (IC50 > 0.3 to 30 µM), and a panel containing 116-receptors, transporters and other enzymes. Shown to inhibit PER3 nuclear translocation in GFP-PER3 and CKIε-cotransfected COS7 cells (EC50 = 290 nM), and induce phase delays in circadian rhythms of monkeys & rats model (10 - 100 mg, s.c.); further, attenuate the locomotor stimulant response to methamphetamine.
          Catalogue Number218716
          Brand Family Calbiochem®
          Synonyms4-(3-Cyclohexyl-5-(4-fluorophenyl)-3H-imidazol-4-yl)-pyrimidin-2-ylamine, 2HCl
          References
          ReferencesBryant, C.D., et al. 2009. Psychopharmacology 203, 703.
          Sprouse, J., et al. 2009. Psychopharmacology 204, 735.
          Badura, L., et al. 2007. J. Pharmacol. Exp. Ther. 322, 730.
          Product Information
          CAS number950912-80-8
          FormOff-white solid
          Hill FormulaC₁₉H₂₀FN₅ • 2HCl
          Chemical formulaC₁₉H₂₀FN₅ • 2HCl
          Hygroscopic Hygroscopic
          Applications
          Biological Information
          Purity≥98% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          S PhraseS: 22-24/25-36/37/39

          Do not breathe dust.
          Avoid contact with skin and eyes.
          Wear suitable protective clothing, gloves and eye/face protection.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsSoluble in DMSO (< 100 mM) or H2O ( < 100 mM); aliquot & store at -20*C; stable for 6 months. Most likely to compete with ATP.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          218716

          References

          Reference overview
          Bryant, C.D., et al. 2009. Psychopharmacology 203, 703.
          Sprouse, J., et al. 2009. Psychopharmacology 204, 735.
          Badura, L., et al. 2007. J. Pharmacol. Exp. Ther. 322, 730.