216201 | Carboxyatractyloside, Potassium Salt, Xanthium sibiricum - CAS 35988-42-2 - Calbiochem

216201
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₃₁H₄₃O₁₈S₂K₃•3H₂O 35988-42-2

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      216201-2MG
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          Plastic ampoule 2 mg
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          216201-5MG
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              Description
              OverviewToxic compound isolated from the plant Xanthium sibiricum. A highly selective and potent inhibitor of adenine nucleotide translocator (ANT) (Ki < 10 nM) and inducer of permeability transition pore opening. Stabilizes the nucleoside binding site of ANT on the cytoplasmic side of the inner membrane and blocks the exchange of matrix ATP and cytoplasmic ADP. Does not affect the activity of mitochondrial multiple conductance channel (MCC).
              CAS No. refers to that of the free acid.
              Catalogue Number216201
              Brand Family Calbiochem®
              SynonymsC-ATR, CAT
              References
              ReferencesPebay-Peyroula, E., et al. 2003. Nature 426, 39.
              Huber, T., et al. 1999. Biochemistry 38, 762.
              Fiore, C., et al. 1998. Biochimie 80, 137.
              Lohret, T.A., et al. 1996. J. Biol. Chem. 271, 4846.
              Product Information
              CAS number35988-42-2
              FormWhite solid
              Hill FormulaC₃₁H₄₃O₁₈S₂K₃•3H₂O
              Chemical formulaC₃₁H₄₃O₁₈S₂K₃•3H₂O
              Hygroscopic Hygroscopic
              Structure formula ImageStructure formula Image
              Applications
              Biological Information
              Purity≥95% by HPLC
              Physicochemical Information
              Dimensions
              Materials Information
              Toxicological Information
              Safety Information according to GHS
              Safety Information
              R PhraseR: 23/24/25

              Toxic by inhalation, in contact with skin and if swallowed.
              S PhraseS: 36/37-45

              Wear suitable protective clothing and gloves.
              In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
              Product Usage Statements
              Storage and Shipping Information
              Ship Code Ambient Temperature Only
              Toxicity Toxic
              Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
              Storage -20°C
              Protect from Moisture Protect from moisture
              Hygroscopic Hygroscopic
              Do not freeze Ok to freeze
              Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
              Packaging Information
              Transport Information
              Supplemental Information
              Specifications

              Documentation

              SDS

              Title

              Safety Data Sheet (SDS) 

              Certificates of Analysis

              TitleLot Number
              216201

              References

              Reference overview
              Pebay-Peyroula, E., et al. 2003. Nature 426, 39.
              Huber, T., et al. 1999. Biochemistry 38, 762.
              Fiore, C., et al. 1998. Biochimie 80, 137.
              Lohret, T.A., et al. 1996. J. Biol. Chem. 271, 4846.
              Data Sheet

              Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

              Revision27-November-2008 RFH
              SynonymsC-ATR, CAT
              DescriptionToxic compound isolated from the plant Xanthium sibiricum. A highly selective and potent inhibitor of adenine nucleotide translocator (ANT) (Ki <10 nM) and inducer of permeability transition pore opening. Stabilizes the nucleoside binding site of ANT on the cytoplasmic side of the inner membrane and blocks the exchange of matrix ATP and cytoplasmic ADP. Does not affect the activity of mitochondrial multiple conductance channel (MCC). CAS No. refers to that of the free acid.
              FormWhite solid
              CAS number35988-42-2
              Chemical formulaC₃₁H₄₃O₁₈S₂K₃•3H₂O
              Structure formulaStructure formula
              Purity≥95% by HPLC
              SolubilityH₂O (10 mg/ml)
              Storage -20°C
              Hygroscopic
              Protect from moisture
              Do Not Freeze Ok to freeze
              Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
              Toxicity Toxic
              ReferencesPebay-Peyroula, E., et al. 2003. Nature 426, 39.
              Huber, T., et al. 1999. Biochemistry 38, 762.
              Fiore, C., et al. 1998. Biochimie 80, 137.
              Lohret, T.A., et al. 1996. J. Biol. Chem. 271, 4846.