211275 Capsaicin

211275
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₈H₂₇NO₃ 404-86-4

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      211275-100MG
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          Glass bottle 100 mg
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          Description
          OverviewAn active constituent of cayenne pepper with excitatory and desensitizing effects on a subset of primary afferent sensory neurons. An antagonist of acetylcholine-induced responses in rat PC12 cells. Exhibits anti-nociceptive and anti-inflammatory effects. Inhibits NF-κB activation by TNF. Reversibly inhibits platelet aggregation.
          Catalogue Number211275
          Brand Family Calbiochem®
          Synonyms[(E)-N-(4-Hydroxy-3-methoxyphenyl)methyl]-8-methyl-6-nonenamide
          References
          ReferencesSingh, S., et al. 1996. J. Immunol. 157, 4412.
          Nakazawa, K., et al. 1994. Br. J. Pharmacol. 113, 296.
          Simmons, D.D., et al. 1994. Int. J. Dev. Neurosci. 12, 517.
          Takaki, M., et al. 1994. J. Mol. Cell. Cardiol. 26, 1227.
          Bevan, S., and Szolcsanyi, J. 1990. Trends Pharmacol. Sci. 11, 330.
          Pernow, B., et al. 1985. J. Immunol. 135, 8125.
          Product Information
          CAS number404-86-4
          FormOff-white solid
          Hill FormulaC₁₈H₂₇NO₃
          Chemical formulaC₁₈H₂₇NO₃
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Purity≥98% by TLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          RTECSRA8530000
          Safety Information
          R PhraseR: 25-41-48

          Toxic if swallowed.
          Risk of serious damage to eyes.
          Danger of serious damage to health by prolonged exposure.
          S PhraseS: 26-36/37/39-45

          In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
          Wear suitable protective clothing, gloves and eye/face protection.
          In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Toxic
          Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
          Storage +15°C to +30°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          211275

          References

          Reference overview
          Singh, S., et al. 1996. J. Immunol. 157, 4412.
          Nakazawa, K., et al. 1994. Br. J. Pharmacol. 113, 296.
          Simmons, D.D., et al. 1994. Int. J. Dev. Neurosci. 12, 517.
          Takaki, M., et al. 1994. J. Mol. Cell. Cardiol. 26, 1227.
          Bevan, S., and Szolcsanyi, J. 1990. Trends Pharmacol. Sci. 11, 330.
          Pernow, B., et al. 1985. J. Immunol. 135, 8125.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision25-July-2012 JSW
          Synonyms[(E)-N-(4-Hydroxy-3-methoxyphenyl)methyl]-8-methyl-6-nonenamide
          DescriptionAn active constituent of cayenne pepper. Has excitatory and desensitizing effects on a subset of primary afferent sensory neurons. An antagonist of acetylcholine-induced respones in rat pheochromocytoma cells. Exhibits antinociceptive and anti-inflammatory effects. Inhibits NF-κB activation by TNF. Reversibly inhibits platelet aggregation.
          FormOff-white solid
          CAS number404-86-4
          RTECSRA8530000
          Chemical formulaC₁₈H₂₇NO₃
          Structure formulaStructure formula
          Purity≥98% by TLC
          SolubilityEthanol (5 mg/ml)
          Storage +15°C to +30°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
          Toxicity Toxic
          Merck USA index14, 1768
          ReferencesSingh, S., et al. 1996. J. Immunol. 157, 4412.
          Nakazawa, K., et al. 1994. Br. J. Pharmacol. 113, 296.
          Simmons, D.D., et al. 1994. Int. J. Dev. Neurosci. 12, 517.
          Takaki, M., et al. 1994. J. Mol. Cell. Cardiol. 26, 1227.
          Bevan, S., and Szolcsanyi, J. 1990. Trends Pharmacol. Sci. 11, 330.
          Pernow, B., et al. 1985. J. Immunol. 135, 8125.