208851 Calyculin A, Discodermia calyx - CAS 101932-71-2 - Calbiochem

208851
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₅₀H₈₁N₄O₁₅P 101932-71-2

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      208851-10UG
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          Glass bottle 10 μg
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          Description
          OverviewA cell-permeable inhibitor of protein phosphatase 2A (PP2A; IC50 = 0.5-1 nM) and protein phosphatase 1 (PP1; IC50 = 2 nM). A non-phorbol ester type tumor promoter that induces oxidative DNA damage. Selectively increases the efficacy of AMPA receptor-mediated synaptic transmission at excitatory synapses. Also known to prevent γ-radiation induced apoptosis in Burkitt’s lymphoma cell line BM13674. Also available as a 100 µM solution in DMSO (Cat. No. 508226).
          Catalogue Number208851
          Brand Family Calbiochem®
          References
          ReferencesMurakami, N., et al. 1994. Neurosci. Lett. 176, 181.
          Takeuchi, T., et al. 1994. Biochem. Biophys. Res. Commun. 205, 1803.
          Figurov, A., et al. 1993. Eur. J. Neurosci. 5, 1083.
          Song, Q., and Lavin, M.F. 1993. Biochem. Biophys. Res. Commun. 190, 47.
          Gopalakrishna, R., et al. 1992. Biochem. Biophys. Res. Commun. 189, 950.
          Carl, A., et al. 1991. Am. J. Physiol. 261, C387.
          Suganuma, M., et al. 1990. Cancer Res. 50, 3521.
          Cohen, P. 1989. Annu. Rev. Biochem. 58, 453.
          Cohen, P., et al. 1989. J. Biol. Chem. 264, 21435.
          Ishihara, H., et al. 1989. Biochem. Biophys. Res. Commun. 159, 871.
          Kato, Y., et al. 1988. J. Org. Chem. 53, 3930.
          Kato, Y., et al. 1986. J. Am. Chem. Soc. 108, 2780.
          Product Information
          CAS number101932-71-2
          ATP CompetitiveN
          FormClear film to white crystalline powder
          Hill FormulaC₅₀H₈₁N₄O₁₅P
          Chemical formulaC₅₀H₈₁N₄O₁₅P
          Hygroscopic Hygroscopic
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetPP2A
          Primary Target IC<sub>50</sub>0.5-1 nM and 2 nM against protein phosphatase 2A (PP2A) and protein phosphatase 1 (PP1)
          Purity≥98% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          R PhraseR: 23/24/25-38

          Toxic by inhalation, in contact with skin and if swallowed.
          Irritating to skin.
          S PhraseS: 26-36/37/39-45

          In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
          Wear suitable protective clothing, gloves and eye/face protection.
          In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Toxic
          Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
          Storage -20°C
          Protect from Light Protect from light
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 12 months at 4°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          208851

          References

          Reference overview
          Murakami, N., et al. 1994. Neurosci. Lett. 176, 181.
          Takeuchi, T., et al. 1994. Biochem. Biophys. Res. Commun. 205, 1803.
          Figurov, A., et al. 1993. Eur. J. Neurosci. 5, 1083.
          Song, Q., and Lavin, M.F. 1993. Biochem. Biophys. Res. Commun. 190, 47.
          Gopalakrishna, R., et al. 1992. Biochem. Biophys. Res. Commun. 189, 950.
          Carl, A., et al. 1991. Am. J. Physiol. 261, C387.
          Suganuma, M., et al. 1990. Cancer Res. 50, 3521.
          Cohen, P. 1989. Annu. Rev. Biochem. 58, 453.
          Cohen, P., et al. 1989. J. Biol. Chem. 264, 21435.
          Ishihara, H., et al. 1989. Biochem. Biophys. Res. Commun. 159, 871.
          Kato, Y., et al. 1988. J. Org. Chem. 53, 3930.
          Kato, Y., et al. 1986. J. Am. Chem. Soc. 108, 2780.

          Brochure

          Title
          DNA Repair Pathway Poster
          Protease and Phosphatase Inhibitor Cocktails Brochure
          Protein Phosphatases Technical Bulletin

          Citations

          Title
        • Carole M. Liedtke, Xiangyun Wang and Nicole D. Smallwood. (2005) Role for protein phosphatase 2A in the regulation of calu-3 epithelial Na+-K+-2Cl-, type 1 co-transport function. Journal of Biological Chemistry 280, 25491-25498.
        • Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision29-June-2011 JSW
          DescriptionCell-permeable protein phosphatase 2A (PP2A) inhibitor (IC50 = 0.5-1.0 nM). Also inhibits protein phosphatase 1 (PP1; IC50 = 2 nM). A non-phorbol ester type tumor promoter that induces oxidative DNA damage. Selectively increases the efficacy of AMPA receptor-mediated synaptic transmission at excitatory synapses. Recently, it has been used to study the regulation of Ca2+-activated K+ channels in smooth muscle and to correlate shape changes in fibroblasts with the degree of protein phosphorylation. Also known to prevent γ-radiation induced apoptosis in Burkitt's lymphoma cell line BM13674.
          FormClear film to white crystalline powder
          Intert gas (Yes/No) Packaged under inert gas
          CAS number101932-71-2
          Chemical formulaC₅₀H₈₁N₄O₁₅P
          Structure formulaStructure formula
          Purity≥98% by HPLC
          SolubilityDMSO or Ethanol (2 mg/ml)
          Storage -20°C
          Hygroscopic
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 12 months at 4°C.
          Toxicity Toxic
          ReferencesMurakami, N., et al. 1994. Neurosci. Lett. 176, 181.
          Takeuchi, T., et al. 1994. Biochem. Biophys. Res. Commun. 205, 1803.
          Figurov, A., et al. 1993. Eur. J. Neurosci. 5, 1083.
          Song, Q., and Lavin, M.F. 1993. Biochem. Biophys. Res. Commun. 190, 47.
          Gopalakrishna, R., et al. 1992. Biochem. Biophys. Res. Commun. 189, 950.
          Carl, A., et al. 1991. Am. J. Physiol. 261, C387.
          Suganuma, M., et al. 1990. Cancer Res. 50, 3521.
          Cohen, P. 1989. Annu. Rev. Biochem. 58, 453.
          Cohen, P., et al. 1989. J. Biol. Chem. 264, 21435.
          Ishihara, H., et al. 1989. Biochem. Biophys. Res. Commun. 159, 871.
          Kato, Y., et al. 1988. J. Org. Chem. 53, 3930.
          Kato, Y., et al. 1986. J. Am. Chem. Soc. 108, 2780.
          Citation
        • Carole M. Liedtke, Xiangyun Wang and Nicole D. Smallwood. (2005) Role for protein phosphatase 2A in the regulation of calu-3 epithelial Na+-K+-2Cl-, type 1 co-transport function. Journal of Biological Chemistry 280, 25491-25498.