208725 | Calphostin C, Cladosporium cladosporioides - CAS 121263-19-2 - Calbiochem

208725
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₄₄H₃₈O₁₄ 121263-19-2

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      208725-100UG
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          Plastic ampoule 100 μg
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          208725-50UG
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              Description
              OverviewA cell permeable, highly specific inhibitor of protein kinase C (IC50 = 50 nM) that interacts with the protein’s regulatory domain by competing at the binding site of diacylglycerol and phorbol esters. Does not compete with Ca2+ or phospholipids. At higher concentrations inhibits myosin light chain kinase (IC50 > 5 µM), protein kinase A (IC50 > 50 µM), protein kinase G (IC50 > 25 µM), and p60v-src (IC50 > 50 µM). Induces apoptotic DNA fragmentation and cell death in HL-60 human promyelocytic leukemia cells. Requires brief exposure to light for activation.
              Catalogue Number208725
              Brand Family Calbiochem®
              SynonymsUCN-1028c
              References
              ReferencesJarvis, W.D., et al. 1994. Cancer Res. 54, 1707.
              Svetlov, S., and Nigami, S. 1993. Biochim. Biophys. Acta 1177, 75.
              Gopalakrishna, R., et al. 1992. FEBS Lett. 314, 149.
              Shimamato, H., et al. 1992. Br. J. Pharmacol. 107, 282.
              Bruns, R.F., et al. 1991. Biochem. Biophys. Res. Commun. 176, 288.
              Tamaoki, T., et al. 1990. Biotechnology 8, 732.
              Kobayashi, E., et al. 1989. Biochem. Biophys. Res. Commun. 159, 548.
              Product Information
              CAS number121263-19-2
              ATP CompetitiveN
              FormLight brown lyophilized solid
              Hill FormulaC₄₄H₃₈O₁₄
              Chemical formulaC₄₄H₃₈O₁₄
              ReversibleN
              Structure formula ImageStructure formula Image
              Applications
              Biological Information
              Primary TargetPKC
              Primary Target IC<sub>50</sub>50 nM against protein kinase C
              Purity≥95% by HPLC
              Physicochemical Information
              Cell permeableY
              Dimensions
              Materials Information
              Toxicological Information
              Safety Information according to GHS
              Safety Information
              Product Usage Statements
              Storage and Shipping Information
              Ship Code Ambient Temperature Only
              Toxicity Standard Handling
              Storage +2°C to +8°C
              Protect from Light Protect from light
              Do not freeze Ok to freeze
              Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
              Packaging Information
              Transport Information
              Supplemental Information
              Specifications

              Documentation

              SDS

              Title

              Safety Data Sheet (SDS) 

              Certificates of Analysis

              TitleLot Number
              208725

              References

              Reference overview
              Jarvis, W.D., et al. 1994. Cancer Res. 54, 1707.
              Svetlov, S., and Nigami, S. 1993. Biochim. Biophys. Acta 1177, 75.
              Gopalakrishna, R., et al. 1992. FEBS Lett. 314, 149.
              Shimamato, H., et al. 1992. Br. J. Pharmacol. 107, 282.
              Bruns, R.F., et al. 1991. Biochem. Biophys. Res. Commun. 176, 288.
              Tamaoki, T., et al. 1990. Biotechnology 8, 732.
              Kobayashi, E., et al. 1989. Biochem. Biophys. Res. Commun. 159, 548.

              Brochure

              Title
              PKC Pathway Poster PDF ( 676 KB )

              Citations

              Title
            • Martha E. O'Donnnell, et al. (2005) Arginine Vasopressin Stimulation of Cerebral Microvascular Endothelial Cell Na-K-Cl Cotransporter Activity is V1 Receptor and [Ca] Dependent. American Journal of Physiology Cell Physiology 289, C283-C292.
            • Yi Dai, et al. (2004) Proteinase-activated receptor 2-mediated potentiation of transient receptor potential vanilloid subfamily 1 activity reveals a mechanism for proteinase-induced inflammatory pain. Journal of Neuroscience 24, 4293-4299.
            • Data Sheet

              Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

              Revision28-May-2008 RFH
              SynonymsUCN-1028c
              DescriptionCell-permeable, highly specific inhibitor of protein kinase C (IC50 = 50 nM) that interacts with the protein's regulatory domain by competing at the binding site of diacylglycerol and phorbol esters. At higher concentrations inhibits myosin light chain kinase (IC50 > 5 µM), protein kinase A (IC50 > 50 µM), protein kinase G (IC50 > 25 µM), and p60v-src protein tyrosine kinase (IC50 > 50 µM). Does not compete with Ca2+ or phospholipids. Also induces apoptotic DNA fragmentation and cell death in HL-60 human promyelocytic leukemia cells. Inhibition of PKC is dependent on exposure to light in cell-free systems. Ordinary fluorescent light is sufficient for full activation.
              FormLight brown lyophilized solid
              CAS number121263-19-2
              Chemical formulaC₄₄H₃₈O₁₄
              Structure formulaStructure formula
              Purity≥95% by HPLC
              SolubilityDMSO (1 mg/ml) or Ethanol
              Storage +2°C to +8°C
              Protect from light
              Do Not Freeze Ok to freeze
              Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
              Toxicity Standard Handling
              ReferencesJarvis, W.D., et al. 1994. Cancer Res. 54, 1707.
              Svetlov, S., and Nigami, S. 1993. Biochim. Biophys. Acta 1177, 75.
              Gopalakrishna, R., et al. 1992. FEBS Lett. 314, 149.
              Shimamato, H., et al. 1992. Br. J. Pharmacol. 107, 282.
              Bruns, R.F., et al. 1991. Biochem. Biophys. Res. Commun. 176, 288.
              Tamaoki, T., et al. 1990. Biotechnology 8, 732.
              Kobayashi, E., et al. 1989. Biochem. Biophys. Res. Commun. 159, 548.
              Citation
            • Martha E. O'Donnnell, et al. (2005) Arginine Vasopressin Stimulation of Cerebral Microvascular Endothelial Cell Na-K-Cl Cotransporter Activity is V1 Receptor and [Ca] Dependent. American Journal of Physiology Cell Physiology 289, C283-C292.
            • Yi Dai, et al. (2004) Proteinase-activated receptor 2-mediated potentiation of transient receptor potential vanilloid subfamily 1 activity reveals a mechanism for proteinase-induced inflammatory pain. Journal of Neuroscience 24, 4293-4299.