208902 | Calpastatin Peptide - Calbiochem

208902
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₁₄₂H₂₃₀N₃₆O₄₄S

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      208902-500UG
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          Glass bottle 500 μg
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          Description
          OverviewA 27-amino acid, cell-permeable peptide encoded by exon 1B of human calpastatin that acts as a potent inhibitor of calpain I and calpain II (IC50 = 20 nM for purified rabbit calpain II). Does not inhibit either papain or trypsin. Blocks the down-regulation of protein kinase Cε (PKCε) in rat pituitary GH4C1 cells stimulated by thyrotropin-releasing hormone (TRH).
          Catalogue Number208902
          Brand Family Calbiochem®
          SynonymsCS Peptide
          References
          ReferencesEto, A., et al. 1995. J. Biol. Chem. 270, 25115.
          Kawasaki, J., et al. 1989. J. Biochem. 106, 274.
          Maki, M., et al. 1989. J. Biol. Chem. 264, 18866.
          Product Information
          ATP CompetitiveN
          FormWhite lyophilized solid
          FormulationSupplied as a trifluoroacetate salt.
          Hill FormulaC₁₄₂H₂₃₀N₃₆O₄₄S
          Chemical formulaC₁₄₂H₂₃₀N₃₆O₄₄S
          Hygroscopic Hygroscopic
          ReversibleN
          Applications
          Biological Information
          Primary Targetcalpain 2
          Primary Target IC<sub>50</sub>20 nM against calpain II
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableY
          Peptide SequenceAc-Asp-Pro-Met-Ser-Ser-Thr-Tyr-Ile-Glu-Glu-Leu-Gly-Lys-Arg-Glu-Val-Thr-Ile-Pro-Pro-Lys-Tyr-Arg-Glu-Leu-Leu-Ala-NH₂
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          208902

          References

          Reference overview
          Eto, A., et al. 1995. J. Biol. Chem. 270, 25115.
          Kawasaki, J., et al. 1989. J. Biochem. 106, 274.
          Maki, M., et al. 1989. J. Biol. Chem. 264, 18866.

          Brochure

          Title
          Calcium Metabolism and Related Products Brochure

          Citations

          Title
        • Ping Han, et al. (2005) Suppression of Cyclin-Dependent Kinase 5 Activation by Amyloid Precursor Protein: A Novel Excitoprotective Mechanism Involving Modulation of Tau Phosphorylation. Journal of Neuroscience 25, 11542-11552.
        • Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision28-May-2008 RFH
          SynonymsCS Peptide
          DescriptionA 27-amino acid, peptide encoded by exon 1B of human calpastatin that acts as a cell-permeable and potent inhibitor of calpain I and calpain II (IC50 = 20 nM for purified rabbit calpain II). Does not inhibit either papain or trypsin. Blocks the down-regulation of protein kinase Cε (PKCε) in rat pituitary GH4C1 cells stimulated by thyrotropin-releasing hormone (TRH).
          FormWhite lyophilized solid
          FormulationSupplied as a trifluoroacetate salt.
          Chemical formulaC₁₄₂H₂₃₀N₃₆O₄₄S
          Peptide SequenceAc-Asp-Pro-Met-Ser-Ser-Thr-Tyr-Ile-Glu-Glu-Leu-Gly-Lys-Arg-Glu-Val-Thr-Ile-Pro-Pro-Lys-Tyr-Arg-Glu-Leu-Leu-Ala-NH₂
          Purity≥95% by HPLC
          SolubilityH₂O (1 mg/ml) or 1% Acetic Acid (1 mg/ml)
          Storage -20°C
          Hygroscopic
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesEto, A., et al. 1995. J. Biol. Chem. 270, 25115.
          Kawasaki, J., et al. 1989. J. Biochem. 106, 274.
          Maki, M., et al. 1989. J. Biol. Chem. 264, 18866.
          Citation
        • Ping Han, et al. (2005) Suppression of Cyclin-Dependent Kinase 5 Activation by Amyloid Precursor Protein: A Novel Excitoprotective Mechanism Involving Modulation of Tau Phosphorylation. Journal of Neuroscience 25, 11542-11552.
        • Related Products & Applications

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          Categories

          Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Proteases Inhibitors > Calpain Inhibitors