208900 Calpastatin, Human, Recombinant, Domain I - Calbiochem

208900
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      Overview

      Replacement Information

      Key Specifications Table

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      208900-1MG
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          Glass bottle 1 mg
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          Description
          OverviewDomain I of human calpastatin. Endogenous protease inhibitor that acts specifically on Calpain-1 (Cat. No. 208712). Exhibits greater inhibitory potency than calpain inhibitors I and II.
          Catalogue Number208900
          Brand Family Calbiochem®
          References
          ReferencesSalamino, F., et al. 1994. Biochem. Biophys. Res. Commun. 199, 1326.
          Uemori, T., et al. 1990. Biochem. Biophys. Res. Commun. 166, 1485.
          Asada, K., et al. 1989. J. Enzyme Inhib. 3, 49.
          Product Information
          ATP CompetitiveN
          DeclarationNot available for sale in Japan.
          FormWhite lyophilized solid
          ReversibleN
          Applications
          Biological Information
          Biological activity50 nM completely inhibits the activity of 7.5 µg/ml calpain I
          Primary Targetcalpain-1
          Purityhomogeneous by SDS-PAGE
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Dry Ice Only
          Toxicity Standard Handling
          Storage -20°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          208900

          References

          Reference overview
          Salamino, F., et al. 1994. Biochem. Biophys. Res. Commun. 199, 1326.
          Uemori, T., et al. 1990. Biochem. Biophys. Res. Commun. 166, 1485.
          Asada, K., et al. 1989. J. Enzyme Inhib. 3, 49.

          Brochure

          Title
          Calcium Metabolism and Related Products Brochure
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision28-May-2008 RFH
          DescriptionAn endogenous protease inhibitor that acts specifically on Calpain I (Cat. No. 208712), a Ca2+-dependent cysteine protease. Widely distributed in mammalian and avian cells. Has better inhibitory action than Calpain Inhibitor I (Cat. No. 208719) and Calpain Inhibitor II (Cat. No. 208721). Calpastatin corresponds to domain I of human calpastatin. The inhibitory sequence of human domain I consists of at least 18 amino acid residues.
          FormWhite lyophilized solid
          Purityhomogeneous by SDS-PAGE
          Biological activity50 nM completely inhibits the activity of 7.5 µg/ml calpain I
          SolubilityH₂O (1 mg/ml) or Aqueous Buffers (1 mg/ml)
          Storage -20°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesSalamino, F., et al. 1994. Biochem. Biophys. Res. Commun. 199, 1326.
          Uemori, T., et al. 1990. Biochem. Biophys. Res. Commun. 166, 1485.
          Asada, K., et al. 1989. J. Enzyme Inhib. 3, 49.

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          Categories

          Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Proteases Inhibitors