208733 Calpain Inhibitor Set - Calbiochem

208733
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      Overview

      Replacement Information

      Key Specifications Table

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      208733-1SET
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      Limited AvailabilityLimited Availability
      Stocked 
      Discontinued
      Limited Quantities Available
      Available
        Remaining : Will advise
          Remaining : Will advise
          Will advise
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          Contact Customer Service

          Glass bottle 1 set
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          Description
          OverviewContains 5 mg of ALLN (Cat. No. 208719), 25 mg of Calpain Inhibitor III (Cat. No. 208722), 5 mg of Calpeptin (Cat. No. 03-34-0051), 1 mg of EST (Cat. No. 330005), and 5 mg of PD 150606 (Cat. No. 513022).
          Catalogue Number208733
          Brand Family Calbiochem®
          References
          ReferencesJohnson, G.V.W., and Guttmann, R.P. 1997. BioEssays 19, 1011.
          Kampfl, A., et al. 1997. J. Neurotauma 14, 121.
          Sorimachi, H., et al., 1997. Biochem. J. 328, 721.
          Bartus, R.T., et al. 1995. Neurol. Res. 17, 249.
          Wang, K.K.W., and Yuen, P-W. 1994. Trends Pharmacol. Sci. 15, 412.
          Saito, K., et al. 1993. Proc. Natl. Acad. Sci. USA 90, 2628.
          Goll, D.E., et al. 1992. BioEssays 14, 549.
          Product Information
          FormSolid
          ReversibleN
          Applications
          Biological Information
          Primary Targetcalpain 1, calpain 2
          Primary Target K<sub>i</sub>8 nM
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          R PhraseR: 36/37/38

          Irritating to eyes, respiratory system and skin.
          S PhraseS: 26-36

          In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
          Wear suitable protective clothing.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Multiple Toxicity Values, refer to MSDS
          Storage -20°C
          Protect from Light Protect from light
          Protect from Moisture Protect from moisture
          Do not freeze Ok to freeze
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          208733

          References

          Reference overview
          Johnson, G.V.W., and Guttmann, R.P. 1997. BioEssays 19, 1011.
          Kampfl, A., et al. 1997. J. Neurotauma 14, 121.
          Sorimachi, H., et al., 1997. Biochem. J. 328, 721.
          Bartus, R.T., et al. 1995. Neurol. Res. 17, 249.
          Wang, K.K.W., and Yuen, P-W. 1994. Trends Pharmacol. Sci. 15, 412.
          Saito, K., et al. 1993. Proc. Natl. Acad. Sci. USA 90, 2628.
          Goll, D.E., et al. 1992. BioEssays 14, 549.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision28-May-2008 RFH
          DescriptionCalpains are a family of calcium-dependent thiol-proteases that act on a wide variety of cytoskeletal, membrane-associated, and regulatory proteins. There are two major isoforms: calpain I (µ-form) and calpain II (m-form), which differ in their calcium requirement for activation Calpains are composed of heterodimers of 80 kDa and a 30 kDa subunits. The 80 kDa unit has the catalytic site and is unique to each isozyme, whereas the 30 kDa unit is the regulatory subunit and is common to both µ- and m-isozymes.

          More recently, attention has been focused on the pathological significance of calcium accumulation in the central nervous system following cerebral ischemia and traumatic brain injury. Over-activation of NMDA, kainate, and AMPA receptors in the brain leads to sustained influx of Ca2+ through the voltage-gated calcium channels. Overexpression of calpains has been positively linked to both acute and chronic neurodegenerative processes including ischemia, trauma, and Alzheimer's disease. In Alzheimer's disease the ratio of active (76 kDa) to inactive (80 kDa) µ-calpain is reported to be much higher Calpain-dependent proteolysis is usually the late-stage common pathway towards cell death induced by excitotoxic compounds, hence, a selective inhibition of calpains to limit neuronal damage appears to be a viable therapeutic measure.
          FormSolid
          Intert gas (Yes/No) Packaged under inert gas
          Storage -20°C
          Protect from moisture
          Protect from light
          Do Not Freeze Ok to freeze
          Toxicity Multiple Toxicity Values, refer to MSDS
          ReferencesJohnson, G.V.W., and Guttmann, R.P. 1997. BioEssays 19, 1011.
          Kampfl, A., et al. 1997. J. Neurotauma 14, 121.
          Sorimachi, H., et al., 1997. Biochem. J. 328, 721.
          Bartus, R.T., et al. 1995. Neurol. Res. 17, 249.
          Wang, K.K.W., and Yuen, P-W. 1994. Trends Pharmacol. Sci. 15, 412.
          Saito, K., et al. 1993. Proc. Natl. Acad. Sci. USA 90, 2628.
          Goll, D.E., et al. 1992. BioEssays 14, 549.