208734 | Calmodulin Binding Domain - CAS 115044-69-4 - Calbiochem

208734
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₀₃H₁₈₅N₃₁O₂₄S 115044-69-4

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      208734-1MG
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          Plastic ampoule 1 mg
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          Description
          OverviewPotent calmodulin antagonist. Inhibits activation of calmodulin-dependent protein kinase II (IC50 = 52 nM). Interacts with the catalytic core of CaM kinase II as a pseudosubstrate.
          Catalogue Number208734
          Brand Family Calbiochem®
          SynonymsCalmodulin antagonist, CaM kinase II 290-309
          References
          ReferencesJames, P., et al. 1995. Trends Biochem. Sci. 20, 38.
          Mukherji, S., and Soderling, T.R. 1995. J. Biol. Chem. 270, 14062.
          Yazawa, M., et al. 1992. Biochemistry 31, 3171.
          Payne, M.E., et al. 1988. J. Biol. Chem. 263, 7190.
          Product Information
          CAS number115044-69-4
          ATP CompetitiveN
          FormWhite lyophilized solid
          FormulationSupplied as a trifluoroacetate salt.
          Hill FormulaC₁₀₃H₁₈₅N₃₁O₂₄S
          Chemical formulaC₁₀₃H₁₈₅N₃₁O₂₄S
          Hygroscopic Hygroscopic
          ReversibleN
          Sold on the basis of peptide contentY
          Applications
          Biological Information
          Primary TargetCalmodulin dependent Protein Kinase-2
          Primary Target IC<sub>50</sub>52 nM against calmodulin-dependent protein kinase II
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableN
          Peptide ContentY
          Peptide SequenceH-Leu-Lys-Lys-Phe-Asn-Ala-Arg-Arg-Lys-Leu-Lys-Gly-Ala-Ile-Leu-Thr-Thr-Met-Leu-Ala-OH
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Aqueous stock solutions are stable for up to 1 year at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          208734

          References

          Reference overview
          James, P., et al. 1995. Trends Biochem. Sci. 20, 38.
          Mukherji, S., and Soderling, T.R. 1995. J. Biol. Chem. 270, 14062.
          Yazawa, M., et al. 1992. Biochemistry 31, 3171.
          Payne, M.E., et al. 1988. J. Biol. Chem. 263, 7190.

          Brochure

          Title
          Calcium Metabolism and Related Products Brochure
          Calmodulin and Related Products Technical Bulletin
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision28-May-2008 RFH
          SynonymsCalmodulin antagonist, CaM kinase II 290-309
          DescriptionA potent calmodulin antagonist that inhibits Ca2+/calmodulin-dependent protein kinase II (IC50 = 52 nM) and Ca2+/calmodulin-dependent phosphodiesterase (IC50 = 1.1 nM).
          FormWhite lyophilized solid
          FormulationSupplied as a trifluoroacetate salt.
          CAS number115044-69-4
          Chemical formulaC₁₀₃H₁₈₅N₃₁O₂₄S
          Peptide SequenceH-Leu-Lys-Lys-Phe-Asn-Ala-Arg-Arg-Lys-Leu-Lys-Gly-Ala-Ile-Leu-Thr-Thr-Met-Leu-Ala-OH
          Purity≥95% by HPLC
          SolubilityH₂O
          Storage -20°C
          Hygroscopic
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Aqueous stock solutions are stable for up to 1 year at -20°C.
          Toxicity Standard Handling
          ReferencesJames, P., et al. 1995. Trends Biochem. Sci. 20, 38.
          Mukherji, S., and Soderling, T.R. 1995. J. Biol. Chem. 270, 14062.
          Yazawa, M., et al. 1992. Biochemistry 31, 3171.
          Payne, M.E., et al. 1988. J. Biol. Chem. 263, 7190.