208665 | Calmidazolium Chloride - CAS 57265-65-3 - Calbiochem

208665
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₃₁H₂₃Cl₇N₂O 57265-65-3

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      208665-10MG
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          Plastic ampoule 10 mg
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          Description
          OverviewA cell-permeable calmodulin antagonist. At least 150 times more potent than Trifluoperazine (Cat. No. 642150) as an inhibitor of brain calmodulin-dependent phosphodiesterase (IC50 = 10 nM). An inhibitor of voltage-gated Ca2+ channels. Stimulates the release of nitric oxide in neuroblastoma cells. Also acts as a strong non-competitive inhibitor of skeletal muscle sarcoplasmic reticulum Ca2+-ATPase (Ki = 60 nM). Known to prolong cardiac refractoriness in vivo.
          Note: easily adheres to glass in aqueous solution.
          Catalogue Number208665
          Brand Family Calbiochem®
          SynonymsCompound R 24571
          References
          ReferencesHu, J., and El-Fakahany, E.E. 1993. NeuroReport. 4, 198.
          Nakazawa, K., et al. 1993. Br. J. Pharmacol. 109, 137.
          Yuasa, T., and Muto, S. 1992. Arch. Biochem. Biophys. 296, 175.
          Ichikawa, M., et al. 1991. J. Membrane Biol. 120, 211.
          Silver, P.J., et al. 1989. Cardiovasc. Drug Ther. 3, 675.
          Anderson, K.W., et al. 1984. J. Biol. Chem. 259, 11487.
          Gietzen, L., et al. 1982. Biochem. J. 207, 541.
          Van Belle, H. 1981. Cell Calcium 2, 483.
          Levin, R.N., and Weiss, B. 1979. J. Pharmacol. Exp. Therap. 208, 454.
          Product Information
          CAS number57265-65-3
          ATP CompetitiveN
          FormWhite solid
          Hill FormulaC₃₁H₂₃Cl₇N₂O
          Chemical formulaC₃₁H₂₃Cl₇N₂O
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary Targetbrain calmodulin-dependent phosphodiesterase
          Primary Target IC<sub>50</sub>10 nM against brain calmodulin-dependent phosphodiesterase
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C) for long term storage or refrigerate (4°C) for short-term storage. DMSO stock solutions are stable for up to 2 months -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          208665

          References

          Reference overview
          Hu, J., and El-Fakahany, E.E. 1993. NeuroReport. 4, 198.
          Nakazawa, K., et al. 1993. Br. J. Pharmacol. 109, 137.
          Yuasa, T., and Muto, S. 1992. Arch. Biochem. Biophys. 296, 175.
          Ichikawa, M., et al. 1991. J. Membrane Biol. 120, 211.
          Silver, P.J., et al. 1989. Cardiovasc. Drug Ther. 3, 675.
          Anderson, K.W., et al. 1984. J. Biol. Chem. 259, 11487.
          Gietzen, L., et al. 1982. Biochem. J. 207, 541.
          Van Belle, H. 1981. Cell Calcium 2, 483.
          Levin, R.N., and Weiss, B. 1979. J. Pharmacol. Exp. Therap. 208, 454.

          Brochure

          Title
          Calcium Metabolism and Related Products Brochure
          Calmodulin and Related Products Technical Bulletin
          Channel Blockers Technical Bulletin
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision18-June-2009 JSW
          SynonymsCompound R 24571
          DescriptionA cell-permeable calmodulin antagonist. An analog of sepazonium that is at least 150 times more potent than Trifluoperazine (Cat. No. 642150) as an inhibitor of brain Ca2+-calmodulin-dependent phosphodiesterase (IC50 = 10 nM). Inhibits voltage-gated Ca2+ channels and stimulates the release of nitric oxide in neuroblastoma cells. Also, acts as a strong inhibitor of calcium-dependent Ca2+-ATPase in erythrocytes. Known to prolong cardiac refractory period in vivo.
          FormWhite solid
          CAS number57265-65-3
          Chemical formulaC₃₁H₂₃Cl₇N₂O
          Structure formulaStructure formula
          Purity≥95% by HPLC
          SolubilityDMSO (10 mg/ml) or EtOH (10 mg/ml). Note: readily adheres to glass in aqueous solution.
          Storage -20°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C) for long term storage or refrigerate (4°C) for short-term storage. DMSO stock solutions are stable for up to 2 months -20°C.
          Toxicity Standard Handling
          ReferencesHu, J., and El-Fakahany, E.E. 1993. NeuroReport. 4, 198.
          Nakazawa, K., et al. 1993. Br. J. Pharmacol. 109, 137.
          Yuasa, T., and Muto, S. 1992. Arch. Biochem. Biophys. 296, 175.
          Ichikawa, M., et al. 1991. J. Membrane Biol. 120, 211.
          Silver, P.J., et al. 1989. Cardiovasc. Drug Ther. 3, 675.
          Anderson, K.W., et al. 1984. J. Biol. Chem. 259, 11487.
          Gietzen, L., et al. 1982. Biochem. J. 207, 541.
          Van Belle, H. 1981. Cell Calcium 2, 483.
          Levin, R.N., and Weiss, B. 1979. J. Pharmacol. Exp. Therap. 208, 454.