207000 | Calcineurin Autoinhibitory Peptide - Calbiochem

207000
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₁₂₄H₂₀₅N₃₉O₃₉S₂

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      207000-250UG
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          Plastic ampoule 250 μg
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          Description
          OverviewSpecific calcineurin inhibitor. Corresponds to the C-terminal domain (residues 457-482) of the calmodulin-binding domain of calcineurin (PP2B). Inhibits Mn2+-stimulated calcineurin activity (IC50 = 10 µM using 32P-myosin light chain as a substrate) but has no effect on Ni2+-stimulated enzyme activity. Does not inhibit CaM kinase II, protein phosphatase 1 or 2A.
          Catalogue Number207000
          Brand Family Calbiochem®
          SynonymsITSFEEAKGLDRINERMPPRRDAMP
          References
          ReferencesPerrino, B.A., et al. 1995. J. Biol. Chem. 270, 340.
          Yokoyama, Y., and Wang, J.H. 1994. FEBS Lett. 337, 128.
          Yokoyama, N., et al. 1993. Arch. Biochem. Biophys. 300, 615.
          Matsui, H., et al. 1991. Biochem. Int. 24, 1119.
          Hashimoto, Y., et al. 1990. J. Biol. Chem. 265, 1924.
          Product Information
          ATP CompetitiveN
          FormLyophilized
          FormulationSupplied as a trifluoroacetate salt.
          Hill FormulaC₁₂₄H₂₀₅N₃₉O₃₉S₂
          Chemical formulaC₁₂₄H₂₀₅N₃₉O₃₉S₂
          Hygroscopic Hygroscopic
          ReversibleN
          Sold on the basis of peptide contentY
          Applications
          Biological Information
          Primary TargetMn2+-stimulated calcineurin activity
          Primary Target IC<sub>50</sub>10 µM using 32P-myosin light chain as a substrate
          Purity≥97% by HPLC
          Physicochemical Information
          Cell permeableN
          Peptide ContentY
          Peptide SequenceH-Ile-Thr-Ser-Phe-Glu-Glu-Ala-Lys-Gly-Leu-Asp-Arg-Ile-Asn-Glu-Arg-Met-Pro-Pro-Arg-Arg-Asp-Ala-Met-Pro-OH
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Aqueous stock solutions are stable for up to 2 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          207000

          References

          Reference overview
          Perrino, B.A., et al. 1995. J. Biol. Chem. 270, 340.
          Yokoyama, Y., and Wang, J.H. 1994. FEBS Lett. 337, 128.
          Yokoyama, N., et al. 1993. Arch. Biochem. Biophys. 300, 615.
          Matsui, H., et al. 1991. Biochem. Int. 24, 1119.
          Hashimoto, Y., et al. 1990. J. Biol. Chem. 265, 1924.

          Brochure

          Title
          Protein Phosphatases Technical Bulletin
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision20-October-2008 JSW
          SynonymsITSFEEAKGLDRINERMPPRRDAMP
          DescriptionCorresponds to a C-terminal domain (residues 457-482) of the calmodulin-binding domain of calcineurin. Specific calcineurin inhibitor. Does not inhibit CaM kinase II, protein phosphatase I or 2A. Inhibits Mn2+-stimulated calcineurin activity (IC50 = 10 µM using 32P myosin light chain as a substrate) but has no effect on Ni2+-stimulated activity.
          FormLyophilized
          FormulationSupplied as a trifluoroacetate salt.
          Chemical formulaC₁₂₄H₂₀₅N₃₉O₃₉S₂
          Peptide SequenceH-Ile-Thr-Ser-Phe-Glu-Glu-Ala-Lys-Gly-Leu-Asp-Arg-Ile-Asn-Glu-Arg-Met-Pro-Pro-Arg-Arg-Asp-Ala-Met-Pro-OH
          Purity≥97% by HPLC
          SolubilityH₂O
          Storage -20°C
          Hygroscopic
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Aqueous stock solutions are stable for up to 2 months at -20°C.
          Toxicity Standard Handling
          ReferencesPerrino, B.A., et al. 1995. J. Biol. Chem. 270, 340.
          Yokoyama, Y., and Wang, J.H. 1994. FEBS Lett. 337, 128.
          Yokoyama, N., et al. 1993. Arch. Biochem. Biophys. 300, 615.
          Matsui, H., et al. 1991. Biochem. Int. 24, 1119.
          Hashimoto, Y., et al. 1990. J. Biol. Chem. 265, 1924.