206700 | Calcein-AM - CAS 148504-34-1 - Calbiochem

206700
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₄₆H₄₆N₂O₂₃ 148504-34-1

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      206700-1MG
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          Plastic ampoule 1 mg
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          Description
          OverviewA cell-permeable, non-fluorescent, and hydrophobic compound, which is rapidly hydrolyzed by intracellular esterases releasing the membrane-impermeable, hydrophilic, and intensely fluorescent calcein. Can also be used for imaging mitochondrial permeability pore transition. Calcein is better retained by viable cells than fluorescein, carboxyfluorescein, or BCECF, and its fluorescence is brighter in a variety of mammalian cell types. Useful for assessing adhesion, cell viability, chemotaxis, and multidrug resistance (MDR).
          Catalogue Number206700
          Brand Family Calbiochem®
          SynonymsCalcein-acetoxymethyl Ester, Diacetate, CAL-AM
          References
          ReferencesDhar, S., et al. 1998. Eur. J. Pharmacol. 346, 315.
          Essodaigui, M., et al. 1998. Biochemistry 37, 2243.
          Lemasters, J.J., et al. 1998. Biochim. Biophys. Acta 1366, 177.
          Feller, N., et al. 1995. Br. J. Cancer 72, 543.
          Feller, N., et al. 1995. FEBS Lett. 368, 385.
          Product Information
          CAS number148504-34-1
          ATP CompetitiveN
          FormOff-white solid
          Hill FormulaC₄₆H₄₆N₂O₂₃
          Chemical formulaC₄₆H₄₆N₂O₂₃
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetImaging mitochondrial permeability pore transition
          Purity≥90% by HPLC
          Physicochemical Information
          Cell permeableY
          Emission max.
          Excitation max.
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          206700

          References

          Reference overview
          Dhar, S., et al. 1998. Eur. J. Pharmacol. 346, 315.
          Essodaigui, M., et al. 1998. Biochemistry 37, 2243.
          Lemasters, J.J., et al. 1998. Biochim. Biophys. Acta 1366, 177.
          Feller, N., et al. 1995. Br. J. Cancer 72, 543.
          Feller, N., et al. 1995. FEBS Lett. 368, 385.

          Brochure

          Title
          Dyes and Stains Technical Bulletin
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision31-March-2008 JSW
          SynonymsCalcein-acetoxymethyl Ester, Diacetate, CAL-AM
          DescriptionA cell-permeable, nonfluorescent, and hydrophobic compound, which is rapidly hydrolyzed by cytoplasmic esterases inside the cell, releasing the membrane-impermeable, hydrophilic, and intensely fluorescent calcein (excitation maximum: 494 nm; emission maximum: 517 nm). A cytosolic fluorophore that can also be used imaging mitochondrial permeability pore transition. Calcein is better retained by viable cells than fluorescein, carboxyfluorescein, and BCECF and its fluorescence is brighter in a variety of mammalian cell types. Useful for assessing adhesion, cell viability, chemotaxis and multidrug resistance (MDR).
          FormOff-white solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number148504-34-1
          Chemical formulaC₄₆H₄₆N₂O₂₃
          Structure formulaStructure formula
          Purity≥90% by HPLC
          SolubilityDMSO (5 mg/ml)
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C.
          Toxicity Standard Handling
          ReferencesDhar, S., et al. 1998. Eur. J. Pharmacol. 346, 315.
          Essodaigui, M., et al. 1998. Biochemistry 37, 2243.
          Lemasters, J.J., et al. 1998. Biochim. Biophys. Acta 1366, 177.
          Feller, N., et al. 1995. Br. J. Cancer 72, 543.
          Feller, N., et al. 1995. FEBS Lett. 368, 385.