238100 | CRM1 Inhibitor III - Calbiochem

238100
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical Formula
      C₁₆H₁₂BrClN₂O₂

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      238100-10MG
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          Glass bottle 10 mg
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          Description
          OverviewA cell-permeable butenediamide compound that acts as a potent, active site cysteine reactive irreversible inhibitor of CRM1/exportin 1. Shown to selectively repress agonist-mediated nuclear export of HDAC4/5, Rev and NFAT proteins in neonatal rat ventricular myocytes (NRVMs; EC50 = 2.2 and 3.5 nM for GFP-HDAC5 and GFP-HIV Rev) and suppress hypertrophic growth of NRVMs (EC50 = 52 nM for ANF expression inhibition) with negligible effect either on the phosphorylation of HDAC5 or on the kinase activities of PKD and CaMKII at 1 µM.
          Catalogue Number238100
          Brand Family Calbiochem®
          Synonyms(Z)-But-2-enedioic acid (4ʹ-bromophenyl)amide (3ʹʹ-chlorophenyl)amide, Chromosome Region Maintenance 1 Protein Inhibitor III, Exportin 1 Inhibitor III, XPO1 Inhibitor III
          References
          ReferencesMonovich, L., et al. 2009. Biochim Biophys Acta. 1789, 422.
          Product Information
          FormYellow powder
          Hill FormulaC₁₆H₁₂BrClN₂O₂
          Chemical formulaC₁₆H₁₂BrClN₂O₂
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Purity≥95% by HPLC
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          238100

          References

          Reference overview
          Monovich, L., et al. 2009. Biochim Biophys Acta. 1789, 422.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision27-July-2012 JSW
          Synonyms(Z)-But-2-enedioic acid (4ʹ-bromophenyl)amide (3ʹʹ-chlorophenyl)amide, Chromosome Region Maintenance 1 Protein Inhibitor III, Exportin 1 Inhibitor III, XPO1 Inhibitor III
          DescriptionA cell-permeable butenediamide compound that acts as a potent, active site cysteine reactive irreversible inhibitor of CRM1/exportin 1. Shown to selectively repress agonist-mediated nuclear export of HDAC4/5, Rev and NFAT proteins in neonatal rat ventricular myocytes (NRVMs; EC50 = 2.2 and 3.5 nM for GFP-HDAC5 and GFP-HIV Rev) and suppress hypertrophic growth of NRVMs (EC50 = 52 nM for ANF expression inhibition) with negligible effect either on the phosphorylation of HDAC5 or on the kinase activities of PKD and CaMKII at 1 µM.
          FormYellow powder
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₁₆H₁₂BrClN₂O₂
          Structure formulaStructure formula
          Purity≥95% by HPLC
          SolubilityDMSO (100 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesMonovich, L., et al. 2009. Biochim Biophys Acta. 1789, 422.