203890 | CRAC Channel Inhibitor, BTP2 - CAS 223499-30-7 - Calbiochem

203890
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₅H₉F₆N₅OS 223499-30-7

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      203890-5MG
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          Plastic ampoule 5 mg
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          Description
          OverviewA cell-permeable pyrazole that acts as a more potent blocker of Stim1 and Orai1-coupled CRAC (Ca2+ release-activated Ca2+) channel-mediated SOCE (store-operated Ca2+ entry) in RBL-2H3 cells (IC50 = 590 nM by Fura-2; peak current density pA/pF = -1.13 and -7.50, respectively, with or without 3 µM BTP2/Pyr2 by whole cell clamp) than the transient receptor potential cation channel TRPC3-mediated ROCE (receptor-operated Ca2+ entry) inTRPC3-expressing HEK293 cells (IC50 = 4.21 µM by Fura-2; pA/pF = -1.54 and -18.50, respectively, with or without 3 µM BTP2/Pyr2). A great complement to Pyr 3 (Cat. No. 648490), Pyr6, and Pyr10 in Ca2+ signaling studies.
          Catalogue Number203890
          Brand Family Calbiochem®
          Synonyms[N-{4-[3,5-bis(Trifluoromethyl)-1H-pyrazol-1-yl]phenyl}-4-methyl-1,2,3-thiadiazole-5-carboxamide], TPRC3 Channel Inhibitor II, Pyr2
          References
          ReferencesSchleifier, H., et al. 2012. Br J Pharmacol In Press
          Yonetoku, Y., et al. 2006. Bioorg. Med. Chem. 14, 5370.
          Yonetoku, Y., et al. 2006. Bioorg. Med. Chem. 14, 4750.
          Zitt, C., et al. 2004. J. Biol. Chem. 279, 12927.
          Trevillyan, J.M., et al. 2001. J. Biol. Chem. 276, 48118.
          Djuric, S.W., et al. 2000. J. Med. Chem. 43, 2975.
          Product Information
          CAS number223499-30-7
          ATP CompetitiveN
          FormSolid
          Hill FormulaC₁₅H₉F₆N₅OS
          Chemical formulaC₁₅H₉F₆N₅OS
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          ApplicationCRAC Channel Inhibitor, BTP2, CAS 223499-30-7, is a cell-permeable, potent blocker of Stim1 and Orai1-coupled Ca2+ release-activated Ca2+ channel-mediated SOCE in RBL-2H3 cells (IC50 = 590 nM).
          Biological Information
          Primary TargetCRAC Channel
          Primary Target IC<sub>50</sub>590 nM by Fura-2
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          203890

          References

          Reference overview
          Schleifier, H., et al. 2012. Br J Pharmacol In Press
          Yonetoku, Y., et al. 2006. Bioorg. Med. Chem. 14, 5370.
          Yonetoku, Y., et al. 2006. Bioorg. Med. Chem. 14, 4750.
          Zitt, C., et al. 2004. J. Biol. Chem. 279, 12927.
          Trevillyan, J.M., et al. 2001. J. Biol. Chem. 276, 48118.
          Djuric, S.W., et al. 2000. J. Med. Chem. 43, 2975.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision21-June-2013 JSW
          Synonyms[N-{4-[3,5-bis(Trifluoromethyl)-1H-pyrazol-1-yl]phenyl}-4-methyl-1,2,3-thiadiazole-5-carboxamide], TPRC3 Channel Inhibitor II, Pyr2
          DescriptionA cell-permeable pyrazole that acts as a more potent blocker of Stim1 and Orai1-coupled CRAC (Ca2+ release-activated Ca2+) channel-mediated SOCE (store-operated Ca2+ entry) in RBL-2H3 cells (IC50 = 590 nM by Fura-2; peak current density pA/pF = -1.13 and -7.50, respectively, with or without 3 µM BTP2/Pyr2 by whole cell clamp) than the transient receptor potential cation channel TRPC3-mediated ROCE (receptor-operated Ca2+ entry) inTRPC3-expressing HEK293 cells (IC50 = 4.21 µM by Fura-2; pA/pF = -1.54 and -18.50, respectively, with or without 3 µM BTP2/Pyr2). A great complement to Pyr 3 (Cat. No. 648490), Pyr6, and Pyr10 in Ca2+ signaling studies.
          FormSolid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number223499-30-7
          Chemical formulaC₁₅H₉F₆N₅OS
          Structure formulaStructure formula
          Purity≥95% by HPLC
          SolubilityDMSO (5 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Standard Handling
          ReferencesSchleifier, H., et al. 2012. Br J Pharmacol In Press
          Yonetoku, Y., et al. 2006. Bioorg. Med. Chem. 14, 5370.
          Yonetoku, Y., et al. 2006. Bioorg. Med. Chem. 14, 4750.
          Zitt, C., et al. 2004. J. Biol. Chem. 279, 12927.
          Trevillyan, J.M., et al. 2001. J. Biol. Chem. 276, 48118.
          Djuric, S.W., et al. 2000. J. Med. Chem. 43, 2975.