236011 | COX-2 Inhibitor I - CAS 416901-58-1 - Calbiochem

236011
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₈H₁₆ClNO₄S 416901-58-1

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      236011-5MG
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          Plastic ampoule 5 mg
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          Description
          OverviewA cell-permeable potent and selective inhibitor of COX-2 from human monocytes (IC50 = 650 nM) and in whole blood (IC50 = 4.3 µM). Displays only very weak activity against COX-1 from human platelets (IC50 > 10 µM) and in whole blood (IC50 > 100 µM).
          Catalogue Number236011
          Brand Family Calbiochem®
          SynonymsLM-1685, Methyl [5-methylsulfonyl-1-(4-chlorobenzyl)-1H-2-indolyl]carboxylate
          References
          ReferencesPalomer, A., et al. 2002. J. Med. Chem. 45, 1402.
          Product Information
          CAS number416901-58-1
          ATP CompetitiveN
          FormWhite solid
          Hill FormulaC₁₈H₁₆ClNO₄S
          Chemical formulaC₁₈H₁₆ClNO₄S
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetCOX-2 from human monocytes
          Primary Target IC<sub>50</sub>650 nM against COX-2 from human monocytes; 4.3 µM against COX-2 in whole blood
          Purity≥97% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          236011

          References

          Reference overview
          Palomer, A., et al. 2002. J. Med. Chem. 45, 1402.

          Brochure

          Title
          Alzheimer's Disease Brochure & Technical Guide
          Biologics 32.3 PDF ( 927 KB )
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision06-April-2011 RFH
          SynonymsLM-1685, Methyl [5-methylsulfonyl-1-(4-chlorobenzyl)-1H-2-indolyl]carboxylate
          DescriptionA cell-permeable potent, selective inhibitor of cyclooxygenase-2 (COX-2) (IC50 = 650 nM, human monocytes COX-2). Shown to specifically inhibit COX-2 in human whole blood (IC50 = 4.3 µM). Displays only weak inhibitory activity against COX-1 from human platelets (19% inhibition at 10 µM) and in whole blood (25% inhibition at 100 µM).
          FormWhite solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number416901-58-1
          Chemical formulaC₁₈H₁₆ClNO₄S
          Structure formulaStructure formula
          Purity≥97% by HPLC
          SolubilityDMSO (100 mg/ml) or MeOH (1 mg/ml)
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesPalomer, A., et al. 2002. J. Med. Chem. 45, 1402.