219670 CFTR Inhibitor-172 - CAS 307510-92-5 - Calbiochem

219670
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₈H₁₀F₃NO₃S₂ 307510-92-5

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      219670-5MG
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          Plastic ampoule 5 mg
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          Description
          OverviewA cell-permeable 2-thio-4-thiazolidinone compound that acts as a potent, reversible, rapid, and voltage-independent inhibitor of CFTR (cystic fibrosis transmembrane conductance regulator)-mediated Cl- transport in human airway cells (Ki ~ 300 nM). It does not prevent elevation of cellular cAMP, nor does it inhibit non-CFTR Cl- channels, MDR-1, ATP-sensitive K+ channels, or a series of other transporters even at concentrations as high as 5 µM. Shown to block cholera toxin-induced intestinal fluid secretion in mice. May be also useful for reducing intestinal fluid loss in other secretory diarrheas. Also available as a 50 mM solution in DMSO (Cat. No. 219674).
          Catalogue Number219670
          Brand Family Calbiochem®
          Synonyms3-[(3-Trifluoromethyl)phenyl]-5-[(4-carboxyphenyl)methylene]-2-thioxo-4-thiazolidinone, CFTRinh-172
          References
          ReferencesYang, H., et al. 2003. J. Biol. Chem. 278, 35079.
          Al-Awqati, Q., et al. 2002. J. Clin. Invest. 110, 1599.
          Ma, T., et al. 2002. J. Clin. Invest. 110, 1651.
          Product Information
          CAS number307510-92-5
          ATP CompetitiveN
          FormYellow solid
          Hill FormulaC₁₈H₁₀F₃NO₃S₂
          Chemical formulaC₁₈H₁₀F₃NO₃S₂
          ReversibleY
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetCFTR
          Primary Target K<sub>i</sub>~ 300 nM against CFTR (cystic fibrosis transmembrane conductance regulator)-mediated Cl- transport in human airway cells
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          219670

          References

          Reference overview
          Yang, H., et al. 2003. J. Biol. Chem. 278, 35079.
          Al-Awqati, Q., et al. 2002. J. Clin. Invest. 110, 1599.
          Ma, T., et al. 2002. J. Clin. Invest. 110, 1651.
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision05-April-2011 RFH
          Synonyms3-[(3-Trifluoromethyl)phenyl]-5-[(4-carboxyphenyl)methylene]-2-thioxo-4-thiazolidinone, CFTRinh-172
          DescriptionA cell-permeable 2-thio-4-thiazolidinone compound that acts as a potent, reversible, rapid, and voltage-independent inhibitor of CFTR (cystic fibrosis transmembrane conductance regulator)-mediated Cl- transport in human airway cells (Ki ~ 300 nM). It does not prevent elevation of cellular cAMP, nor does it inhibit non-CFTR Cl- channels, MDR-1, ATP-sensitive K+ channels, or a series of other transporters even at concentrations as high as 5 µM. Shown to block cholera toxin-induced intestinal fluid secretion in mice. May be also useful for reducing intestinal fluid loss in other secretory diarrheas.
          FormYellow solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number307510-92-5
          Chemical formulaC₁₈H₁₀F₃NO₃S₂
          Structure formulaStructure formula
          Purity≥95% by HPLC
          SolubilityDMSO (5 mg/ml)
          Storage +2°C to +8°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Standard Handling
          ReferencesYang, H., et al. 2003. J. Biol. Chem. 278, 35079.
          Al-Awqati, Q., et al. 2002. J. Clin. Invest. 110, 1599.
          Ma, T., et al. 2002. J. Clin. Invest. 110, 1651.