211200 | CAPE - CAS 104594-70-9 - Calbiochem

211200
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₁₇H₁₆O₄ 104594-70-9

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      211200-25MG
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          Plastic ampoule 25 mg
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          Description
          OverviewA cell-permeable active component of propolis from honeybee hives. Known to have antiviral, anti-inflammatory, and immunomodulatory properties. Has also recently been shown to act as a potent and specific inhibitor of NF-κB activation. An inhibitor of HIV-1 integrase activity. Inhibits the growth of different types of transformed cells. Has been reported to suppress lipid peroxidation. Inhibits ornithine decarboxylase, protein tyrosine kinase (PTK), and lipoxygenase activities. Also induces apoptosis in cloned rat embryo fibroblast (CREF) cells transformed by a number of different oncogenes.
          Catalogue Number211200
          Brand Family Calbiochem®
          SynonymsCaffeic Acid Phenethyl Ester, Synthetic
          References
          ReferencesNicklaus, M.C., et al. 1997. J. Med. Chem. 40, 920.
          Natarajan, K., et al. 1996. Proc. Natl. Acad. Sci. USA 93, 9090.
          Burke, T.R., Jr., et al. 1995. J. Med. Chem. 38, 4171.
          Laranjinha, J., et al. 1995. Arch. Biochem. Biophys. 323, 373.
          Su, Z.-Z., et al. 1995. Anticancer Res. 15, 1841.
          Zheng, Z.S., et al. 1995. Oncol. Res. 7, 445.
          Su, Z.-Z., et al. 1994. Cancer Res. 54, 1865.
          Fesen, M.R., et al. 1993. Proc. Natl. Acad. Sci. USA 90, 2399.
          Guarini, L., et al. 1992. Cell. Mol. Biol. 38, 513.
          Product Information
          CAS number104594-70-9
          ATP CompetitiveN
          FormWhite to off-white solid
          Hill FormulaC₁₇H₁₆O₄
          Chemical formulaC₁₇H₁₆O₄
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          Biological Information
          Primary TargetHIV-integrase
          Purity≥97% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          R PhraseR: 36/37/38

          Irritating to eyes, respiratory system and skin.
          S PhraseS: 26-36

          In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
          Wear suitable protective clothing.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Irritant
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot and freeze at -20°C. Stock solutions are stable for up to 3 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          211200

          References

          Reference overview
          Nicklaus, M.C., et al. 1997. J. Med. Chem. 40, 920.
          Natarajan, K., et al. 1996. Proc. Natl. Acad. Sci. USA 93, 9090.
          Burke, T.R., Jr., et al. 1995. J. Med. Chem. 38, 4171.
          Laranjinha, J., et al. 1995. Arch. Biochem. Biophys. 323, 373.
          Su, Z.-Z., et al. 1995. Anticancer Res. 15, 1841.
          Zheng, Z.S., et al. 1995. Oncol. Res. 7, 445.
          Su, Z.-Z., et al. 1994. Cancer Res. 54, 1865.
          Fesen, M.R., et al. 1993. Proc. Natl. Acad. Sci. USA 90, 2399.
          Guarini, L., et al. 1992. Cell. Mol. Biol. 38, 513.

          Brochure

          Title
          Nitric Oxide and Oxidative Stress Brochure
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision28-May-2008 RFH
          SynonymsCaffeic Acid Phenethyl Ester, Synthetic
          DescriptionA cell-permeable active component of propolis from honeybee hives. Known to have antiviral, anti-inflammatory, and immunomodulatory properties. An inhibitor of HIV-1 integrase activity. Inhibits the growth of different types of transformed cells. Has been reported to suppress lipid peroxidation. Inhibits ornithine decarboxylase, protein tyrosine kinase (PTK) and lipoxygenase activities. Also induces apoptosis in cloned rat embryo fibroblast (CREF) cells transformed by a number of different oncogenes. Has also recently been shown to act as a potent and specific inhibitor of NF-κB activation.
          FormWhite to off-white solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number104594-70-9
          Chemical formulaC₁₇H₁₆O₄
          Structure formulaStructure formula
          Purity≥97% by HPLC
          SolubilityDMSO (200 mg/ml) and Ethanol (50 mg/ml)
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution aliquot and freeze at -20°C. Stock solutions are stable for up to 3 months at -20°C.
          Toxicity Irritant
          ReferencesNicklaus, M.C., et al. 1997. J. Med. Chem. 40, 920.
          Natarajan, K., et al. 1996. Proc. Natl. Acad. Sci. USA 93, 9090.
          Burke, T.R., Jr., et al. 1995. J. Med. Chem. 38, 4171.
          Laranjinha, J., et al. 1995. Arch. Biochem. Biophys. 323, 373.
          Su, Z.-Z., et al. 1995. Anticancer Res. 15, 1841.
          Zheng, Z.S., et al. 1995. Oncol. Res. 7, 445.
          Su, Z.-Z., et al. 1994. Cancer Res. 54, 1865.
          Fesen, M.R., et al. 1993. Proc. Natl. Acad. Sci. USA 90, 2399.
          Guarini, L., et al. 1992. Cell. Mol. Biol. 38, 513.