236603 | C-Reactive Protein, Human Serum, High Purity

236603
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      Overview

      Replacement Information

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      236603-100UG
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          Glass bottle 100 μg
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          Description
          OverviewNative C-reactive protein highly purified from human serum. CRP is a major acute-phase plasma protein that is dramatically elevated in patients with acute-phase conditions. Composed of five identical noncovalently linked subunits. Exhibits Ca2+-dependent binding to a variety of substrates. Important in diagnosis of rheumatoid arthritis. Suitable for immunological studies. In purified states and in plasma the monomeric form (M.W. ~21 kDa) aggregates as a cyclic pentamer. Intended for use as a calibration standard for assays of CRP, for structural and functional studies, and as an antigen for production of antisera. Calibrated by electroimmunoassay against WHO reference standard or equivalent.
          M.W. 23,000 (monomer); 115,000 (pentamer).
          No reaction in ODD and Laurell electroimmunoassay against polyvalent antiserum to normal human serum, antiserum to pooled effusion fluids and monospecific antiserum to human IgG.
          Catalogue Number236603
          Brand Family Calbiochem®
          SynonymsCRP
          References
          ReferencesPaffen, E., et al. 2004. Arterioscler. Thromb. Vasc. Biol. 24, 975.
          Product Information
          CAS number9007-41-4
          FormLiquid
          FormulationIn 140 mM NaCl, 10 mM Tris, 2 mM CaCl₂, 0.1% NaN₃, pH 8.0.
          Applications
          Biological Information
          Purity≥99% by SDS-PAGE
          SourcePrepared from serum that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Dry Ice Only
          Toxicity Standard Handling
          Storage ≤ -70°C
          Avoid freeze/thaw Avoid freeze/thaw
          Do not freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          236603

          References

          Reference overview
          Paffen, E., et al. 2004. Arterioscler. Thromb. Vasc. Biol. 24, 975.

          Citations

          Title
        • Paramita Baruah, et al. (2006) The pattern recognition receptor PTX3 is recruited at the synapse between dying and dendritic cells and edits the cross-presentation of self, viral and tumor antigens. Blood 107, 151-158.
        • Elaine Paffen, Hans L. Vos and Rogier M. Bertina. (2004) C-Reactive Protein Does Not Directly Induce Tissue Factor in Human Monocytes. Arteriosclerosis, Thrombosis, and Vascular Biology 24, 975-981.
        • Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision27-September-2007 RFH
          SynonymsCRP
          DescriptionNative C-reactive protein highly purified from human serum. CRP is a major acute-phase plasma protein that is dramatically elevated in patients with acute-phase conditions. Composed of five identical noncovalently linked subunits. Exhibits Ca2+-dependent binding to a variety of substrates. Important in diagnosis of rheumatoid arthritis. Suitable for immunological studies. In purified states and in plasma the monomeric form (M.W. ~21 kDa) aggregates as a cyclic pentamer. Intended for use as a calibration standard for assays of CRP, for structural and functional studies, and as an antigen for production of antisera. Calibrated by electroimmunoassay against WHO reference standard or equivalent.
          FormLiquid
          FormulationIn 140 mM NaCl, 10 mM Tris, 2 mM CaCl₂, 0.1% NaN₃, pH 8.0.
          SourcePrepared from serum that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
          CAS number9007-41-4
          Purity≥99% by SDS-PAGE
          Storage ≤ -70°C
          Avoid freeze/thaw
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
          Toxicity Standard Handling
          Merck USA index14, 2603
          ReferencesPaffen, E., et al. 2004. Arterioscler. Thromb. Vasc. Biol. 24, 975.
          Citation
        • Paramita Baruah, et al. (2006) The pattern recognition receptor PTX3 is recruited at the synapse between dying and dendritic cells and edits the cross-presentation of self, viral and tumor antigens. Blood 107, 151-158.
        • Elaine Paffen, Hans L. Vos and Rogier M. Bertina. (2004) C-Reactive Protein Does Not Directly Induce Tissue Factor in Human Monocytes. Arteriosclerosis, Thrombosis, and Vascular Biology 24, 975-981.