236608 | C-Reactive Protein, Human, Recombinant, E. coli

236608
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      Overview

      Replacement Information

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      236608-1MG
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          Plastic ampoule 1 mg
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          Description
          OverviewRecombinant, human C-reactive protein expressed in E. coli. CRP is a major acute-phase plasma protein that is dramatically elevated in patients with acute-phase conditions. Composed of five identical noncovalently linked subunits. Exhibits Ca2+-dependent binding to a variety of substrates. Important in diagnosis of rheumatoid arthritis. Suitable for immunological studies. In purified states and in plasma the monomeric form (M.W. ~21 kDa) aggregates as a cyclic pentamer.
          M.W. 23,000 (monomer); 115,000 (pentamer).
          Catalogue Number236608
          Brand Family Calbiochem®
          SynonymsrhCRP
          References
          ReferencesPaffen, E., et al. 2004. Arterioscler. Thromb. Vasc. Biol. 24, 975.
          Ballou, S.P., and Kushner, I. 1992. Adv. Intern. Med. 37, 313.
          Stults, N.L., et al. 1987. Anal. Biochem. 161, 567.
          Woo, P., et al. 1985. J. Biol. Chem. 260, 13384.
          de Beer, F.C., and Pepys, M.B. 1982. J. Immun. Methods 50, 17.
          Product Information
          CAS number9007-41-4
          FormLiquid
          FormulationIn 140 mM NaCl, 20 mM Tris-HCl, 2 mM CaCl₂, 0.05% NaN₃, pH 7.5.
          Applications
          Biological Information
          Physicochemical Information
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Blue Ice Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Do not freeze Yes
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          236608

          References

          Reference overview
          Paffen, E., et al. 2004. Arterioscler. Thromb. Vasc. Biol. 24, 975.
          Ballou, S.P., and Kushner, I. 1992. Adv. Intern. Med. 37, 313.
          Stults, N.L., et al. 1987. Anal. Biochem. 161, 567.
          Woo, P., et al. 1985. J. Biol. Chem. 260, 13384.
          de Beer, F.C., and Pepys, M.B. 1982. J. Immun. Methods 50, 17.

          Citations

          Title
        • Paramita Baruah, et al. (2006) The pattern recognition receptor PTX3 is recruited at the synapse between dying and dendritic cells and edits the cross-presentation of self, viral and tumor antigens. Blood 107, 151-158.
        • Elaine Paffen, Hans L. Vos and Rogier M. Bertina. (2004) C-Reactive Protein Does Not Directly Induce Tissue Factor in Human Monocytes. Arteriosclerosis, Thrombosis, and Vascular Biology 24, 975-981.
        • Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision13-February-2014 JSW
          SynonymsrhCRP
          DescriptionRecombinant, human C-reactive protein expressed in E. coli. CRP is a major acute-phase plasma protein that is dramatically elevated in patients with acute-phase conditions. Composed of five identical noncovalently linked subunits. Exhibits Ca2+-dependent binding to a variety of substrates. Important in diagnosis of rheumatoid arthritis. Suitable for immunological studies. In purified states and in plasma the monomeric form (M.W. ~21 kDa) aggregates as a cyclic pentamer. Intended for use as a calibration standard for assays of CRP, for structural and functional studies, and as an antigen for production of antisera. Calibrated by electroimmunoassay against WHO reference standard or equivalent.
          FormLiquid
          FormulationIn 140 mM NaCl, 20 mM Tris-HCl, 2 mM CaCl₂, 0.05% NaN₃, pH 7.5.
          CAS number9007-41-4
          SolubilityAqueous buffers
          Storage +2°C to +8°C
          Do Not Freeze Yes
          Toxicity Standard Handling
          Merck USA index14, 2603
          ReferencesPaffen, E., et al. 2004. Arterioscler. Thromb. Vasc. Biol. 24, 975.
          Ballou, S.P., and Kushner, I. 1992. Adv. Intern. Med. 37, 313.
          Stults, N.L., et al. 1987. Anal. Biochem. 161, 567.
          Woo, P., et al. 1985. J. Biol. Chem. 260, 13384.
          de Beer, F.C., and Pepys, M.B. 1982. J. Immun. Methods 50, 17.
          Citation
        • Paramita Baruah, et al. (2006) The pattern recognition receptor PTX3 is recruited at the synapse between dying and dendritic cells and edits the cross-presentation of self, viral and tumor antigens. Blood 107, 151-158.
        • Elaine Paffen, Hans L. Vos and Rogier M. Bertina. (2004) C-Reactive Protein Does Not Directly Induce Tissue Factor in Human Monocytes. Arteriosclerosis, Thrombosis, and Vascular Biology 24, 975-981.