203671 | Bongkrekic Acid, Triammonium Salt - CAS 1177154-51-6 - Calbiochem

203671
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₈H₃₅O₇ · 3NH₄ 1177154-51-6

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      203671-500UG
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          Plastic ampoule 500 μg
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          Description
          OverviewActs as a ligand of the adenine nucleotide translocator. A potent inhibitor of mitochondrial megachannel (permeability transition pore). Significantly reduces signs of apoptosis induced by nitric oxide. Prevents the apoptotic breakdown of the inner mitochondrial transmembrane potential (ΔΨm), as well as a number of other phenomena linked to apoptosis.
          Catalogue Number203671
          Brand Family Calbiochem®
          Synonyms3-Carboxymethyl-17-methoxy-6,18,21-trimethyldocosa-2,4,8,12,18,20-heptaenedioic Acid, BA, 3NH₄
          References
          ReferencesHirsch, T., et al. 1998. J. Immunol. 161, 35.
          Horteleno, S., et al. 1997. FEBS Lett. 410, 373.
          Marchetti, P., et al. 1996. J. Exp. Med. 184, 1155.
          Marchetti, P., et al. 1996. J. Immunol. 157, 4830.
          Zamzami, N., et al. 1996. J. Exp. Med. 183, 1533.
          Henderson, P.J., and Lardy, H.A. 1970. J. Biol. Chem. 245, 1319.
          Product Information
          CAS number1177154-51-6
          ATP CompetitiveN
          FormBeige-pink solid
          Hill FormulaC₂₈H₃₅O₇ · 3NH₄
          Chemical formulaC₂₈H₃₅O₇ · 3NH₄
          ReversibleN
          Structure formula ImageStructure formula Image
          Applications
          ApplicationBongkrekic Acid, Triammonium Salt, CAS 1177154-51-6, acts as a ligand of the adenine nucleotide translocator. A potent inhibitor of mitochondrial megachannel (permeability transition pore).
          Biological Information
          Primary TargetMitochondrial mega channel
          Purity≥92% by HPLC
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          R PhraseR: 20/21/22-40

          Harmful by inhalation, in contact with skin and if swallowed.
          Limited evidence of a carcinogenic effect.
          S PhraseS: 36-22

          Wear suitable protective clothing.
          Do not breathe dust.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Dry Ice Only
          Toxicity Harmful & Carcinogenic / Teratogenic
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 year at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications

          Documentation

          SDS

          Title

          Safety Data Sheet (SDS) 

          Certificates of Analysis

          TitleLot Number
          203671

          References

          Reference overview
          Hirsch, T., et al. 1998. J. Immunol. 161, 35.
          Horteleno, S., et al. 1997. FEBS Lett. 410, 373.
          Marchetti, P., et al. 1996. J. Exp. Med. 184, 1155.
          Marchetti, P., et al. 1996. J. Immunol. 157, 4830.
          Zamzami, N., et al. 1996. J. Exp. Med. 183, 1533.
          Henderson, P.J., and Lardy, H.A. 1970. J. Biol. Chem. 245, 1319.

          Brochure

          Title
          Calbiochem Biologics 32.1
          Mitochondrial Metabolism Modulators
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision24-June-2011 JSW
          Synonyms3-Carboxymethyl-17-methoxy-6,18,21-trimethyldocosa-2,4,8,12,18,20-heptaenedioic Acid, BA, 3NH₄
          DescriptionActs as a ligand of the adenine nucleotide translocator. A potent inhibitor of mitochondrial megachannel (permeability transition pore). Significantly reduces signs of apoptosis induced by nitric oxide. Prevents the apoptotic breakdown of the inner mitochondrial transmembrane potential (ΔΨm), as well as a number of other phenomena linked to apoptosis.
          FormBeige-pink solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number1177154-51-6
          Chemical formulaC₂₈H₃₅O₇ · 3NH₄
          Structure formulaStructure formula
          Purity≥92% by HPLC
          SolubilityDMSO (100 mg/ml)
          Storage -20°C
          Protect from light
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 year at -20°C.
          Toxicity Harmful & Carcinogenic / Teratogenic
          Merck USA index14, 1332
          ReferencesHirsch, T., et al. 1998. J. Immunol. 161, 35.
          Horteleno, S., et al. 1997. FEBS Lett. 410, 373.
          Marchetti, P., et al. 1996. J. Exp. Med. 184, 1155.
          Marchetti, P., et al. 1996. J. Immunol. 157, 4830.
          Zamzami, N., et al. 1996. J. Exp. Med. 183, 1533.
          Henderson, P.J., and Lardy, H.A. 1970. J. Biol. Chem. 245, 1319.