203303 Bisindolylmaleimide V - CAS 113963-68-1 - Calbiochem

A cell-permeable negative control compound for protein kinase C inhibition studies (IC₅₀ >100 µM).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 2,3-bis(1H-Indol-3-yl)-N-methylmaleimide, Ro 31-6045

Primary Target: Negative control compound for protein kinase C inhibition
203303
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₁H₁₅N₃O₂ 113963-68-1

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      203303-1MG
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          		 Plastic ampoule 1 mg
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          203303-250UG
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              		 Plastic ampoule 250 μg
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              Description
              OverviewA cell-permeable negative control compound for protein kinase C inhibition studies (IC50 >100 µM). Blocks the activation of mitogen-stimulated protein kinase p70s6k/p85s6k in vivo (IC50 8 µM).
              Catalogue Number203303
              Brand Family Calbiochem®
              Synonyms2,3-bis(1H-Indol-3-yl)-N-methylmaleimide, Ro 31-6045
              References
              ReferencesMarmy-Conus, N., et al. 2002. FEBS Lett. 26094 (In Press) 1-6.
              Davis, P.D., et al. 1992. J. Med. Chem. 35, 177.
              Toullec, D., et al. 1991. J. Biol. Chem. 266, 15771.
              Product Information
              CAS number113963-68-1
              ATP CompetitiveN
              FormRedish orange solid
              Hill FormulaC₂₁H₁₅N₃O₂
              Chemical formulaC₂₁H₁₅N₃O₂
              ReversibleN
              Structure formula ImageStructure formula Image
              Applications
              Biological Information
              Primary TargetNegative control compound for protein kinase C inhibition
              Primary Target IC<sub>50</sub>>100 µM as negative control compound for protein kinase C inhibition; 8 µM in blocking the activation of mitogen-stimulated protein kinase p70s6k/p85s6k in vivo
              Purity≥95% by HPLC
              Physicochemical Information
              Cell permeableY
              Dimensions
              Materials Information
              Toxicological Information
              Safety Information according to GHS
              Safety Information
              Product Usage Statements
              Storage and Shipping Information
              Ship Code Ambient Temperature Only
              Toxicity Standard Handling
              Storage +2°C to +8°C
              Do not freeze Ok to freeze
              Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
              Packaging Information
              Transport Information
              Supplemental Information
              Specifications

              Documentation

              SDS

              Title

              Safety Data Sheet (SDS) 

              Certificates of Analysis

              TitleLot Number
              203303

              References

              Reference overview
              Marmy-Conus, N., et al. 2002. FEBS Lett. 26094 (In Press) 1-6.
              Davis, P.D., et al. 1992. J. Med. Chem. 35, 177.
              Toullec, D., et al. 1991. J. Biol. Chem. 266, 15771.

              Brochure

              Title
              PKC Pathway Poster PDF ( 676 KB )
              Data Sheet

              Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

              Revision20-May-2008 RFH
              Synonyms2,3-bis(1H-Indol-3-yl)-N-methylmaleimide, Ro 31-6045
              DescriptionA cell-permeable negative control compound for protein kinase C inhibition studies (IC50 > 100 µM). Blocks the activation of p70s6k/p85s6k in vivo (IC50 = 8 µM).
              FormRedish orange solid
              CAS number113963-68-1
              Chemical formulaC₂₁H₁₅N₃O₂
              Structure formulaStructure formula
              Purity≥95% by HPLC
              SolubilityDMSO (10 mg/ml) or Methanol (5 mg/ml)
              Storage +2°C to +8°C
              Do Not Freeze Ok to freeze
              Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
              Toxicity Standard Handling
              ReferencesMarmy-Conus, N., et al. 2002. FEBS Lett. 26094 (In Press) 1-6.
              Davis, P.D., et al. 1992. J. Med. Chem. 35, 177.
              Toullec, D., et al. 1991. J. Biol. Chem. 266, 15771.