203291 | Bisindolylmaleimide I, Hydrochloride - CAS 176504-36-2 - Calbiochem

203291
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      Overview

      Replacement Information

      Key Specifications Table

      Empirical FormulaCAS #
      C₂₅H₂₄N₄O₂ · HCl 176504-36-2

      Pricing & Availability

      Catalog NumberAvailability Packaging Qty/Pack Price Quantity
      203291-1MG
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          Plastic ampoule 1 mg
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          203291-250UG
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              Plastic ampoule 250 μg
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              Description
              OverviewAn enhanced water-soluble form of Bisindolylmaleimide I (Cat. No. 203290). A reversible and ATP-competitive inhibitor of protein kinase C (Ki = 10 nM). May inhibit protein kinase A at much higher concentrations (Ki = 2 µM).
              Catalogue Number203291
              Brand Family Calbiochem®
              Synonyms2-[1-(3-Dimethylaminopropyl)-1H-indol-3-yl]-3-(1H-indol-3-yl)maleimide, HCl
              References
              ReferencesLe Panse, R., et al. 1994. Mol. Pharmacol. 46, 445.
              Kuchera, S., et al. 1993. Agents Actions 39, C169.
              Wilkinson, S.E., et al. 1993. Biochem. J. 294, 335.
              Toullec, D., et al. 1991. J. Biol. Chem. 266, 15771.
              Product Information
              CAS number176504-36-2
              ATP CompetitiveY
              FormOrange-red solid
              Hill FormulaC₂₅H₂₄N₄O₂ · HCl
              Chemical formulaC₂₅H₂₄N₄O₂ · HCl
              ReversibleY
              Structure formula ImageStructure formula Image
              Applications
              Biological Information
              Primary TargetProtein kinase C
              Primary Target K<sub>i</sub>10 nM against protein kinase C
              Purity≥95% by HPLC
              Physicochemical Information
              Cell permeableN
              Dimensions
              Materials Information
              Toxicological Information
              Safety Information according to GHS
              Safety Information
              Product Usage Statements
              Storage and Shipping Information
              Ship Code Ambient Temperature Only
              Toxicity Standard Handling
              Storage +2°C to +8°C
              Do not freeze Ok to freeze
              Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 6 months at 4°C.
              Packaging Information
              Transport Information
              Supplemental Information
              Specifications

              Documentation

              SDS

              Title

              Safety Data Sheet (SDS) 

              Certificates of Analysis

              TitleLot Number
              203291

              References

              Reference overview
              Le Panse, R., et al. 1994. Mol. Pharmacol. 46, 445.
              Kuchera, S., et al. 1993. Agents Actions 39, C169.
              Wilkinson, S.E., et al. 1993. Biochem. J. 294, 335.
              Toullec, D., et al. 1991. J. Biol. Chem. 266, 15771.

              Brochure

              Title
              PKC Pathway Poster PDF ( 676 KB )

              Citations

              Title
            • Alexandra Thiel, Mira Heinonen, Johanna Rintahaka, Tuija Hallikainen, and Annabrita Hemmes, Dan A. Dixon, Caj Haglund, and Ari Ristimaki. (2006) EXPRESSION OF CYCLOOXYGENASE-2 IS REGULATED BY GSK-3 IN GASTRIC CANCER CELLS. Journal of Biological Chemistry in press,.
            • Michael J. Cross, et al. (2002) The Shb Adaptor Protein Binds to Tyrosine 766 in the FGFR-1 and Regulates the Ras/MEK/MAPK Pathway via FRS2 Phosphorylation in Endothelial Cells. Molecular Biology of the Cell 13, 2881-2893.
            • Data Sheet

              Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

              Revision08-January-2010 RFH
              Synonyms2-[1-(3-Dimethylaminopropyl)-1H-indol-3-yl]-3-(1H-indol-3-yl)maleimide, HCl
              DescriptionA reversible and ATP-competitive inhibitor of protein kinase C (Ki = 10 nM). Inhibits protein kinase A at much higher concentrations (Ki = 2 µM). An enhanced water soluble form of Bisindolylmaleimide I (Cat. No. 203290).
              FormOrange-red solid
              CAS number176504-36-2
              Chemical formulaC₂₅H₂₄N₄O₂ · HCl
              Structure formulaStructure formula
              Purity≥95% by HPLC
              SolubilityDMSO (20 mg/ml) or H₂O (10 mg/ml)
              Storage +2°C to +8°C
              Do Not Freeze Ok to freeze
              Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 6 months at 4°C.
              Toxicity Standard Handling
              ReferencesLe Panse, R., et al. 1994. Mol. Pharmacol. 46, 445.
              Kuchera, S., et al. 1993. Agents Actions 39, C169.
              Wilkinson, S.E., et al. 1993. Biochem. J. 294, 335.
              Toullec, D., et al. 1991. J. Biol. Chem. 266, 15771.
              Citation
            • Alexandra Thiel, Mira Heinonen, Johanna Rintahaka, Tuija Hallikainen, and Annabrita Hemmes, Dan A. Dixon, Caj Haglund, and Ari Ristimaki. (2006) EXPRESSION OF CYCLOOXYGENASE-2 IS REGULATED BY GSK-3 IN GASTRIC CANCER CELLS. Journal of Biological Chemistry in press,.
            • Michael J. Cross, et al. (2002) The Shb Adaptor Protein Binds to Tyrosine 766 in the FGFR-1 and Regulates the Ras/MEK/MAPK Pathway via FRS2 Phosphorylation in Endothelial Cells. Molecular Biology of the Cell 13, 2881-2893.